PMID: 16532616Mar 15, 2006Paper

Comparison of left anterior descending coronary artery hemodynamics before and after angioplasty

Journal of Biomechanical Engineering
S D RamaswamyKrishnan B Chandran

Abstract

Coronary artery disease (CAD) is characterized by the progression of atherosclerosis, a complex pathological process involving the initiation, deposition, development, and breakdown of the plaque. The blood flow mechanics in arteries play a critical role in the targeted locations and progression of atherosclerotic plaque. In coronary arteries with motion during the cardiac contraction and relaxation, the hemodynamic flow field is substantially different from the other arterial sites with predilection of atherosclerosis. In this study, our efforts focused on the effects of arterial motion and local geometry on the hemodynamics of a left anterior descending (LAD) coronary artery before and after clinical intervention to treat the disease. Three-dimensional (3D) arterial segments were reconstructed at 10 phases of the cardiac cycle for both pre- and postintervention based on the fusion of intravascular ultrasound (IVUS) and biplane angiographic images. An arbitrary Lagrangian-Eulerian formulation was used for the computational fluid dynamic analysis. The measured arterial translation was observed to be larger during systole after intervention and more out-of-plane motion was observed before intervention, indicating substantial alt...Continue Reading

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Citations

Jan 29, 2005·Annals of Biomedical Engineering·S D RamaswamyK B Chandran
Dec 23, 2008·The Annals of Thoracic Surgery·Lindsay C H John
Sep 29, 2011·Korean Circulation Journal·Byoung-Kwon Lee
Jul 23, 2011·Dental Materials Journal·Libor BorákNoriyuki Wakabayashi

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