Abstract
Cardiac contractility modulation (CCM) is a new device-based therapy for advanced systolic heart failure with normal QRS duration and therefore not suitable for cardiac resynchronization therapy (CRT). Left ventricular (LV) reverse remodeling was reported in patients treated with CCM or CRT, however, the extent of response was not compared. This observational study consisted of three groups of patients with symptomatic heart failure and LV ejection fraction <35% despite optimal medical therapy. Group 1 included those received CCM with a QRS duration <120 ms (n=33), Group 2 included those received CRT with a QRS duration of 120-150 ms (n=43), and Group 3 included those received CRT with a QRS duration >150 ms (n=56). LV end-systolic volume (LVESV) was measured at baseline and 3 months later. Age, gender, etiology of heart failure and baseline ejection fraction were comparable. A significant LV reverse remodeling was observed in each group. The degree of LVESV reduction was similar between Group 1 and Group 2 (-11.3 ± 1 1.8 vs. -13.6 ± 18.3%, p=0.833), however, it was greater in Group 3 (-25.0 ± 18.0%, both p<0.01). By using the reduction ≥ 15%, the responder rate was not different between Group 1 (39%) and Group 2 (42%), but sig...Continue Reading
References
Jul 1, 1987·Circulation·H D WhiteC J Wild
Dec 1, 1996·Circulation·M R BristowN Shusterman
Apr 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Satoshi MohriDaniel Burkhoff
Jun 14, 2002·The New England Journal of Medicine·William T AbrahamUNKNOWN MIRACLE Study Group. Multicenter InSync Randomized Clinical Evaluation
Dec 14, 2002·The American Journal of Cardiology·Carlo PapponeShlomo A Ben-Haim
Feb 27, 2004·European Journal of Heart Failure·Hideaki MoritaHani N Sabbah
Apr 16, 2004·European Heart Journal·Guenter StixHerwig Schmidinger
Apr 20, 2004·Journal of Cardiovascular Electrophysiology·Carlo PapponeHerwig Schmidinger
Sep 15, 2004·Journal of Cardiovascular Electrophysiology·Cheuk-Man YuJohn E Sanderson
Mar 9, 2005·The New England Journal of Medicine·John G F ClelandUNKNOWN Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators
Sep 8, 2005·Circulation·Cheuk-Man YuJeroen J Bax
Oct 6, 2005·European Journal of Heart Failure·Corinna B BrunckhorstDaniel Burkhoff
Dec 20, 2005·Journal of the American College of Cardiology·Goo-Yeong ChoYung Lee
Feb 16, 2006·Circulation·Matthew S SuffolettoJohn Gorcsan
Oct 5, 2006·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Suresh B NeelagaruKoonlawee Nademanee
Mar 31, 2007·Journal of Cardiac Failure·Christian ButterHani N Sabbah
May 29, 2007·Journal of the American College of Cardiology·Makoto ImaiHani N Sabbah
Feb 14, 2008·European Heart Journal·Martin M BorggrefeGerhard Hindricks
May 7, 2008·Circulation·Eugene S ChungJaime Murillo
May 8, 2008·Current Heart Failure Reports·Jeffrey Wing-Hong Fung, Cheuk-Man Yu
Sep 9, 2008·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·H NägeleC Eisermann
Nov 29, 2008·Journal of the American College of Cardiology·Cecilia LindeUNKNOWN REVERSE (REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction) Study Group
Mar 28, 2009·Circulation·Sharon Ann HuntClyde W Yancy
Jan 20, 2010·JACC. Cardiovascular Imaging·Cheuk-Man YuJeffrey Wing-Hong Fung
Apr 23, 2011·European Journal of Heart Failure·James WinterG André Ng
Citations
Aug 14, 2013·Nature Reviews. Cardiology·Alexander R LyonDavid S Feldman
Oct 16, 2014·Current Heart Failure Reports·Satish Chandraprakasam, Gina G Mentzer
Feb 15, 2019·Current Heart Failure Reports·James A Mann, William T Abraham
Jan 20, 2017·Herz·X LiuB Yang
Oct 13, 2020·The Journal of International Medical Research·Bin NingYi Dang