Comparison of left ventricular reverse remodeling induced by cardiac contractility modulation and cardiac resynchronization therapy in heart failure patients with different QRS durations

International Journal of Cardiology
Qing ZhangCheuk-Man Yu

Abstract

Cardiac contractility modulation (CCM) is a new device-based therapy for advanced systolic heart failure with normal QRS duration and therefore not suitable for cardiac resynchronization therapy (CRT). Left ventricular (LV) reverse remodeling was reported in patients treated with CCM or CRT, however, the extent of response was not compared. This observational study consisted of three groups of patients with symptomatic heart failure and LV ejection fraction <35% despite optimal medical therapy. Group 1 included those received CCM with a QRS duration <120 ms (n=33), Group 2 included those received CRT with a QRS duration of 120-150 ms (n=43), and Group 3 included those received CRT with a QRS duration >150 ms (n=56). LV end-systolic volume (LVESV) was measured at baseline and 3 months later. Age, gender, etiology of heart failure and baseline ejection fraction were comparable. A significant LV reverse remodeling was observed in each group. The degree of LVESV reduction was similar between Group 1 and Group 2 (-11.3 ± 1 1.8 vs. -13.6 ± 18.3%, p=0.833), however, it was greater in Group 3 (-25.0 ± 18.0%, both p<0.01). By using the reduction ≥ 15%, the responder rate was not different between Group 1 (39%) and Group 2 (42%), but sig...Continue Reading

References

Apr 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Satoshi MohriDaniel Burkhoff
Jun 14, 2002·The New England Journal of Medicine·William T AbrahamUNKNOWN MIRACLE Study Group. Multicenter InSync Randomized Clinical Evaluation
Mar 9, 2005·The New England Journal of Medicine·John G F ClelandUNKNOWN Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators
Oct 6, 2005·European Journal of Heart Failure·Corinna B BrunckhorstDaniel Burkhoff
Oct 5, 2006·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Suresh B NeelagaruKoonlawee Nademanee
May 7, 2008·Circulation·Eugene S ChungJaime Murillo
May 8, 2008·Current Heart Failure Reports·Jeffrey Wing-Hong Fung, Cheuk-Man Yu
Sep 9, 2008·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·H NägeleC Eisermann
Nov 29, 2008·Journal of the American College of Cardiology·Cecilia LindeUNKNOWN REVERSE (REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction) Study Group
Jan 20, 2010·JACC. Cardiovascular Imaging·Cheuk-Man YuJeffrey Wing-Hong Fung
Apr 23, 2011·European Journal of Heart Failure·James WinterG André Ng

❮ Previous
Next ❯

Citations

Aug 14, 2013·Nature Reviews. Cardiology·Alexander R LyonDavid S Feldman
Oct 16, 2014·Current Heart Failure Reports·Satish Chandraprakasam, Gina G Mentzer
Feb 15, 2019·Current Heart Failure Reports·James A Mann, William T Abraham

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Related Papers

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Thomas SchauChristian Butter
© 2022 Meta ULC. All rights reserved