PMID: 9450849Feb 5, 1998Paper

Comparison of leptin protein levels in Prader-Willi syndrome and control individuals

American Journal of Medical Genetics
Merlin G ButlerM Nicolson

Abstract

Prader-Willi syndrome (PWS) is characterized by early childhood obesity, mental deficiency, hypogonadism, hypotonia, hypopigmentation, short stature, small hands and feet, and a characteristic face. It is the most common genetic cause of obesity and obesity is the most significant health problem for PWS patients. Ob protein (leptin), which is produced by adipose tissue, is thought to play a significant role in obesity; thus, unusually low plasma leptin levels, or relative loss of sensitivity to leptin in PWS subjects, could be an important factor in their obesity. We measured plasma leptin levels in 19 obese and 14 non-obese PWS patients [mean body mass index (BMI) 37.2 and 22.0, respectively] and compared these levels to those of 28 obese controls (mean BMI 35.5) and 16 non-obese control individuals (mean BMI 21.6). The mean plasma leptin concentration (ng/ml) for obese PWS subjects was 33.4 and 23.6 for non-obese PWS subjects. Obese control leptin was 36.2 ng/ml and non-obese control was 9.9. Among the control groups, leptin levels in females were significantly higher than those in males; the obese males and females had significantly higher leptin than their respective non-obese counterparts. These differences did not hold tr...Continue Reading

Citations

Sep 5, 2008·PloS One·Gilberto J Paz-FilhoJulio Licinio
Sep 16, 1999·The New England Journal of Medicine·I S FarooqiS O'Rahilly
Jan 22, 2008·Frontiers in Neuroendocrinology·William DaviesLawrence S Wilkinson
Mar 18, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·G Paz-FilhoJ Licinio
Jun 29, 1999·The Journal of Laboratory and Clinical Medicine·M G CarlsonM G Butler
Jan 27, 2018·International Journal of Pediatric Endocrinology·I Caroline van NieuwpoortMadeleine L Drent

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