Comparison of lesions induced by intra-articular injections of quinolones and compounds damaging cartilage components in rat femoral condyles

Journal of Toxicology and Environmental Health
S TakadaS Takayama

Abstract

Twenty-five microliters of a 2% saline solution of levofloxacin (LVFX) or ciprofloxacin (CPFX) was injected every other day for 2 wk into the knee joint space of CD rats (weighing 62.7-86.7 g) from the age of 3 wk. Early in the course of injection, histologic examination revealed chondrocyte necrosis without marked matrix change in the articular cartilage of the femoral condyles adjacent to the intercondylar groove. After 7 injections, the surface and intermediate zones of the articular cartilage showed extensive necrosis, sometimes with cavity formation in the center of the same portion. Papain completely depleted matrix basophilia in all zones throughout the condyle and caused cartilage necrosis with cavity formation. One injection of iodoacetic acid caused necrosis of almost all chondrocytes over the entire condyle, but chondrocytes sometimes remained alive in the portion where cavity formation was induced by quinolones. Chondroitinase depleted the matrix basophilia, and sometimes produced necrotic areas. DNA synthesis inhibitors n-ethylmaleimide, CPT-11, and etoposide (VP-16) caused chondrocyte necrosis, but never caused cavities in the articular cartilage. The DNA synthesis inhibitors n-ethylmaleimide, CPT-11, and hydroxyu...Continue Reading

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Citations

May 23, 1998·Journal of Veterinary Pharmacology and Therapeutics·K YoshidaK Furuhama
May 1, 1995·Journal of Toxicology and Environmental Health·S TakayamaH Shimada
Feb 24, 2001·American Journal of Veterinary Research·C L DavenportD W Richardson
Jan 11, 2000·Journal of the American Veterinary Medical Association·A L BertoneS E Weisbrode
Feb 22, 2000·The Journal of Bone and Joint Surgery. American Volume·P M HuddlestonR Patel
Dec 3, 1999·Antimicrobial Agents and Chemotherapy·M A SimoninB Terlain
Nov 26, 1997·Antimicrobial Agents and Chemotherapy·M MenschikW B Graninger

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