Comparison of Liver Biopsy Findings with the Digestive Disease Week Japan 2004 Scale for Diagnosis of Drug-Induced Liver Injury

Mediators of Inflammation
Akemi TsutsuiHiroko Ikeda

Abstract

The liver biopsy remains a valuable tool in the diagnosis of drug-induced liver injury (DILI). The Digestive Disease Week Japan 2004 (DDW-J) scale proposed as an objective tool for the diagnosis of DILI has been widely used in Japan. So far, the histological features have not been compared with DDW-J scale in detail. Herein, we examined the correlation between liver biopsy findings and clinical features, particularly DDW-J scales. A total of 80 patients with liver injuries of unknown cause were enrolled. Based on the histological findings, these cases were categorized into 3 groups: A (DILI was strongly suspected), B (DILI was suspected), and C (DILI should be considered in the differential diagnosis). Histological groups and DDW-J scale were moderately correlated (κ = 0.60). The mean total DDW-J scale scores were as follows: 4.89 for A, 3.26 for B, and 0.75 for C (p < 0.05). While hepatocellular type was coincided in a majority of cases by histological and DDW-J scale evaluation, cholestatic type was not well coincided. In conclusion, biopsy findings and DDW-J scale were well correlated, and the hepatocellular type of liver injuries was well coincided by both evaluations, though there were several discrepant cases, particularl...Continue Reading

References

Dec 18, 2002·Annals of Internal Medicine·George OstapowiczUNKNOWN U.S. Acute Liver Failure Study Group
Mar 21, 2008·Fundamental & Clinical Pharmacology·Ma Isabel LucenaRaúl J Andrade
Dec 6, 2008·World Journal of Gastroenterology : WJG·Kazuto Tajiri, Yukihiro Shimizu
Jan 10, 2009·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Robert J FontanaUNKNOWN DILIN Study Group
Apr 17, 2010·Gastroenterology·Naga Chalasani, Einar Björnsson
Jun 1, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Einar BjörnssonKeith Lindor
Jun 22, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert J FontanaJay H Hoofnagle
Jun 16, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ayako SuzukiEinar Björnsson
Aug 23, 2011·Gastroenterology·Timothy J DavernUNKNOWN Drug-Induced Liver Injury Network (DILIN)
Sep 17, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Drug-Induced Liver Injury Network (DILIN)

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Citations

Aug 9, 2017·World Journal of Gastroenterology : WJG·Kenichi YoshikawaMasayuki Saruta
Mar 19, 2020·Journal of Gastroenterology and Hepatology·Takashi KitagatayaNaoya Sakamoto
Mar 22, 2020·Scientific Reports·Omkolthoum AlhaddadMohsen Salama

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Methods Mentioned

BETA
biopsy
biopsies

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