Comparison of long-labeled pseudo-continuous arterial spin labeling (ASL) features between young and elderly adults: special reference to parameter selection

Acta Radiologica
Yasuhiro FujiwaraHirohiko Kimura

Abstract

The signal intensity obtained by arterial spin labeling (ASL) depends not only on perfusion signal, but also on arterial transit time (ATT). Although ATT has a more significant effect on accurate regional cerebral blood flow (CBF) calculations, the multiple post-labeling delay (PLD) approach is difficult to use in routine examinations. To optimize imaging parameters for labeling duration (LD) and PLD and to confirm their validity in long-labeled pseudo-continuous ASL. The perfusion signal was simulated in four LDs and theoretical signal-to-noise ratio efficiency (SNReff) was calculated. In vivo studies were performed on a 3.0 T magnetic resonance imaging (MRI) scanner and 15 volunteers were categorized into either the young or elderly adult groups. We compared the differences in CBF values with or without ATT correction. Regarding signal simulation, perfusion signal increased with the length of LD. SNReff also improved with LD, but SNReff plateaued at an LD of 3.0 s. As for the in vivo study, SNR linearly increased along with the LD. The CBF differences with the correction of ATT were larger in the elderly adult group. This trend was most prominent in the longer ATT area in the occipital cortical region. A combination of imagin...Continue Reading

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BETA
PCA

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GraphPad Prism
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