Comparison of Machine Learning Computed Tomography-Based Fractional Flow Reserve and Coronary CT Angiography-Derived Plaque Characteristics with Invasive Resting Full-Cycle Ratio

Journal of Clinical Medicine
Stefan BaumannD Lossnitzer

Abstract

The aim is to compare the machine learning-based coronary-computed tomography fractional flow reserve (CT-FFRML) and coronary-computed tomographic morphological plaque characteristics with the resting full-cycle ratio (RFRTM) as a novel invasive resting pressure-wire index for detecting hemodynamically significant coronary artery stenosis. In our single center study, patients with coronary artery disease (CAD) who had a clinically indicated coronary computed tomography angiography (cCTA) and subsequent invasive coronary angiography (ICA) with pressure wire-measurement were included. On-site prototype CT-FFRML software and on-site CT-plaque software were used to calculate the hemodynamic relevance of coronary stenosis. We enrolled 33 patients (70% male, mean age 68 ± 12 years). On a per-lesion basis, the area under the receiver operating characteristic curve (AUC) of CT-FFRML (0.90) was higher than the AUCs of the morphological plaque characteristics length/minimal luminal diameter4 (LL/MLD4; 0.80), minimal luminal diameter (MLD; 0.77), remodeling index (RI; 0.76), degree of luminal diameter stenosis (0.75), and minimal luminal area (MLA; 0.75). CT-FFRML and morphological plaque characteristics show a significant correlation to ...Continue Reading

References

Mar 15, 1990·Journal of the American College of Cardiology·A S AgatstonR Detrano
Mar 5, 2004·Journal of the American College of Cardiology·Stephan AchenbachWerner G Daniel
Dec 20, 2008·Journal of the American College of Cardiology·W Bob MeijboomPim J de Feyter
Mar 12, 2010·The New England Journal of Medicine·Manesh R PatelPamela S Douglas
Aug 28, 2012·JAMA : the Journal of the American Medical Association·James K MinLaura Mauri
Mar 21, 2017·The New England Journal of Medicine·Matthias GötbergUNKNOWN iFR-SWEDEHEART Investigators
Mar 21, 2017·The New England Journal of Medicine·Justin E DaviesJavier Escaned
Nov 24, 2017·JAMA Cardiology·Stefan BaumannU Joseph Schoepf
May 23, 2018·The New England Journal of Medicine·Panagiotis XaplanterisUNKNOWN FAME 2 Investigators
May 24, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Johan SvanerudZiad A Ali
Jun 2, 2018·Journal of the American College of Cardiology·Hyuk-Jae ChangJames K Min
Nov 8, 2018·European Heart Journal·Franz-Josef Neumann, Miguel Sousa-Uva
Dec 28, 2018·Circulation·Joo Myung LeeBon-Kwon Koo
Oct 31, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Stefan BaumannDirk Lossnitzer

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

SAS
Volcano
CT
FLOW
NXT
FFR ML
Coronary Plaque Analysis
Syngo
DISCOVER
FFR

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