Comparison of manual and automated filaments for evaluation of neuropathic pain behavior in rats

Journal of Pharmacological and Toxicological Methods
Ramakrishna NirogiRenny Abraham

Abstract

The most commonly used Von Frey filaments are productive in evaluating behavioral responses of neuropathic pain in preclinical and clinical research. To reduce the potential experimenter bias, automated instruments are being developed for behavioral assessment. In preclinical research, neuropathic pain models of nerve injury with varied etiology like partial sciatic nerve ligation (PNL), chronic constricted injury (CCI) and spinal nerve ligation (SNL) are employed to screen the analgesic drugs to treat symptoms like allodynia and hyperalgesia. The current study was aimed to validate and compare conventionally used Von Frey monofilaments and automated dynamic plantar aesthesiometer using three different pain models. PNL, CCI and SNL rats were used to compare and validate the assessment of neuropathic pain using Von Frey monofilaments and automated dynamic plantar aesthesiometer. Mechanical allodynia was assessed at various time points to mimic drug testing conditions in neuropathic pain models and anticipated to observe reliable and reproducible paw withdrawal threshold measurements across these models. Consistent paw withdrawal thresholds were observed in all the three models of neuropathic pain with Von Frey monofilaments, whe...Continue Reading

References

Jan 1, 1987·The Journal of Hand Surgery·J Bell-Krotoski, E Tomancik
Jan 1, 1980·Annual Review of Pharmacology and Toxicology·W J Dixon
Nov 20, 1998·Journal of Neuroscience Methods·K A MöllerO G Berge
Jul 20, 2001·British Journal of Anaesthesia·D BridgesA S Rice
Aug 7, 2007·Neuron·Clifford J Woolf, Qiufu Ma
Oct 22, 2008·The International Journal of Neuroscience·Sanja Lovric KojundzicDamir Sapunar
Jul 25, 2009·The Journal of Pain : Official Journal of the American Pain Society·Jianren Mao
Dec 8, 2009·European Journal of Pain : EJP·Amynah Amir Ali PradhanJennifer M A Laird
May 5, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Hue Jung ParkDong Eon Moon

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Citations

Jan 5, 2014·TheScientificWorldJournal·Dhandapani ThangamaniWillias Masocha
Dec 2, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·F GuidaL Luongo
Oct 21, 2016·PloS One·Ana María Jiménez-GarcíaIgnacio Morón
Mar 23, 2018·Social Neuroscience·Andre T WalcottAndrey E Ryabinin
Jan 6, 2019·International Journal of Molecular Sciences·Marina Arribas-BlázquezAntonio R Artalejo
Aug 5, 2019·Neurochemical Research·Jung Woo NamHyung Jun Kim
May 13, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Hai HuangYuelai Chen

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