Comparison of mental health outcomes among adults with psoriasis on biologic versus oral therapies: a population-based study

The Journal of Dermatological Treatment
Nicole SalameApril W Armstrong

Abstract

We sought to compare the impact of biologic versus oral therapies on mental health outcomes among adult U.S. residents with moderate-to-severe psoriasis. We performed a nationwide, cross-sectional study comparing 2,303,534 (weighted) adults with moderate-to-severe psoriasis on biologic versus oral therapies and their associated mental health outcomes using the 2003-2015 Medical Expenditure Panel Survey (MEPS). Mental health outcomes were measured with the Kessler 6 (K6), a validated measure of psychological distress, and Patient Health Questionnaire 2 (PHQ2), a screening tool for depression. The mean K6 score for residents on biologic therapies was significantly lower than that of residents on oral therapies (2.72 [95% CI: 2.27-3.17] versus 3.70 [95% CI: 3.27-4.12]; p < .001). The mean PHQ2 score for residents on biologic therapies was also significantly lower than that of residents on oral therapies (0.540 [95% CI: 0.390-0.690] versus 0.890 [95% CI: 0.749-1.031]; p < .001). Based on adjusted multivariable linear regression models, biologic therapy was associated with significant reductions in K6 (p < .001) and PHQ2 (p = .016) scores compared to oral therapy. Therapeutic choices for psoriasis impact mental health outcomes. Biol...Continue Reading

References

Jan 1, 1990·Journal of Psychiatric Research·D A RegierD S Rae
Mar 1, 1993·International Journal of Dermatology·M A GuptaC N Ellis
Aug 25, 1999·Journal of the American Academy of Dermatology·S R RappD M Reboussin
Mar 22, 2001·Journal of Psychosomatic Research·H L RichardsC J Main
Sep 24, 2002·JAMA : the Journal of the American Medical Association·Constantine G LyketsosSteven DeKosky
Feb 13, 2003·Archives of General Psychiatry·Ronald C KesslerAlan M Zaslavsky
Oct 30, 2003·Medical Care·Kurt KroenkeJanet B W Williams
Dec 4, 2003·American Journal of Clinical Dermatology·Madhulika A Gupta, Aditya K Gupta
Apr 12, 2005·Journal of Psychosomatic Research·Bernd LöweKerstin Gräfe
Apr 27, 2010·Dermatologic Therapy·Jennifer Hayes, John Koo
Sep 13, 2011·Economics and Human Biology·Nathan Tefft
Feb 5, 2013·Archives of Dermatological Research·Johannes WohlrabMichael P Schön
Nov 29, 2013·The Journal of Investigative Dermatology·Emmilia A DowlatshahiTamar Nijsten
Nov 25, 2016·Nature Reviews. Disease Primers·Jacqueline E GrebAlice B Gottlieb
Aug 16, 2017·Journal of the American Academy of Dermatology·Sanminder SinghApril W Armstrong

❮ Previous
Next ❯

Citations

May 9, 2019·JAMA Dermatology·April W Armstrong
Aug 14, 2019·Journal of Intellectual Disability Research : JIDR·K A Woodcock, J Waite
Sep 16, 2020·The Journal of Dermatological Treatment·Vipawee S ChatApril W Armstrong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.