Comparison of Metabolic Outcomes in Children Diagnosed with Type 1 Diabetes Through Research Screening (Diabetes Autoimmunity Study in the Young [DAISY]) Versus in the Community.

Diabetes Technology & Therapeutics
Christine L ChanAndrea K Steck

Abstract

Children with positive islet autoantibodies monitored prospectively avoid metabolic decompensation at type 1 diabetes (T1D) diagnosis. However, the effects of early diagnosis and treatment on preservation of insulin secretion and long-term metabolic control are unknown. We compared characteristics of children detected through research screening (Diabetes Autoimmunity Study in the Young [DAISY]) versus community controls at baseline and, in a subset, 6- and 12-month metabolic outcomes. This was a case-control study comparing DAISY children with T1D to children diagnosed in the general community. All participants underwent mixed-meal tolerance testing; a subset wore a continuous glucose monitoring (CGM) device. Fasting and stimulated C-peptide levels, insulin dose-adjusted hemoglobin A1c (IDAA1c), and CGM variables were compared. Children (21 DAISY, 21 community) were enrolled and matched by age, time of diagnosis, and diabetes duration; 18 were enrolled within 2 months and 24 within 2.5 years on average from diagnosis. In the overall group and the subgroup of participants enrolled 2.5 years from diagnosis, there were no IDAA1c or C-peptide differences between DAISY versus community children. The subgroup of DAISY versus communit...Continue Reading

References

Jul 31, 2001·Lancet·M A Atkinson, G S Eisenbarth
May 31, 2002·The New England Journal of Medicine·Kevan C HeroldJeffrey A Bluestone
Aug 5, 2004·The Journal of Clinical Endocrinology and Metabolism·Jennifer M BarkerUNKNOWN Diabetes Autoimmunity Study in the Young
Oct 1, 2008·Pediatric Diabetes·Jeffrey L MahonUNKNOWN Type 1 Diabetes TrialNet Study Group
Jan 6, 2009·Annals of the New York Academy of Sciences·UNKNOWN TEDDY Study Group
Mar 10, 2009·Diabetes/metabolism Research and Reviews·Jerry P Palmer
May 14, 2009·Diabetes Care·Henrik B MortensenUNKNOWN Hvidoere Study Group on Childhood Diabetes
Jul 10, 2009·Diabetes Care·Carla J GreenbaumUNKNOWN SEARCH Study Group
Jun 20, 2013·JAMA : the Journal of the American Medical Association·Anette G ZieglerGeorge S Eisenbarth
Oct 17, 2013·Diabetes Care·Bruce BuckinghamUNKNOWN Type 1 Diabetes TrialNet Study Group

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Citations

Mar 21, 2019·Pediatric Diabetes·Heba M IsmailUNKNOWN Type 1 Diabetes Trial Net and Diabetes Prevention Trial-Type-1 (DPT-1) Study Groups
Jan 24, 2020·Diabetes Technology & Therapeutics·Rachael L DiSantostefanoCarol Mansfield

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Methods Mentioned

BETA
blood draws
enzyme-linked immunosorbent assay

Software Mentioned

DAISY
SAS

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