PMID: 589351Dec 17, 1977

Comparison of metformin and chlorpropamide in non-obese, maturity-onset diabetics uncontrolled by diet

British Medical Journal
B F Clarke, I W Campbell

Abstract

The clinical effectiveness of metformin was compared with that of chlorpropamide in closely similar groups of 216 non-obese patients recently diagnosed as cases of maturity-onset diabetes that could not be controlled by diet. The incidences of primary and secondary drug failures in each group and the numbers of patients satisfactorily maintained on each of the hypoglycaemic agents throughout the first year proved remarkably similar. In 61 of the successfully treated patients who were studied by crossover to the other drug and observed for a further year the mean blood glucose concentrations at the end of the year were roughly comparable, but the mean weight response was a small loss of 1.5 +/- 3.8 kg with metformin but a gain of 4.6 +/- 3.9 kg with chlorpropamide. Thus for non-obese, maturity-onset diabetics whose disease cannot be controlled by diet and who require oral treatment sulphonylureas and biguanides are equally effective, the choice depending on whether the patient is underweight and the severity of symptoms.

Citations

Sep 1, 1995·Diabetes/metabolism Reviews·I W Campbell, H C Howlett
Jan 1, 1988·European Journal of Clinical Pharmacology·L G McAlpineB M Frier
Jan 1, 1996·Archives of Gerontology and Geriatrics·F GregorioP Filipponi
Jan 1, 1997·The American Journal of Medicine·M B Davidson, A L Peters
Feb 29, 1996·The New England Journal of Medicine·C J Bailey, R C Turner
Dec 1, 1991·The Proceedings of the Nutrition Society·C J Bailey
Feb 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·M A Carpenter, H J Bodansky
Jul 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·S Josephkutty, J M Potter
May 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·P K ChongC M Scrimgeour
Aug 15, 1997·Medizinische Klinik·E Haupt, U Panten
May 28, 2011·Medicina clínica·Pablo B Pedrianes Martín, Pedro L de Pablos Velasco
Apr 19, 2013·Diabetes, Obesity & Metabolism·M MonamiE Mannucci
May 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·C J Bailey
Oct 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·S G RainsR S Elkeles
Mar 3, 2012·Diabetes Research and Clinical Practice·Emily G MoserSatish K Garg
Feb 28, 2001·Diabetes, Obesity & Metabolism·M J Iuorno, J E Nestler
Feb 3, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·F GregorioP Filipponi
Oct 13, 2005·Diabetes, Obesity & Metabolism·Mark O Goodarzi, Michael Bryer-Ash
Jul 1, 1987·Diabetic Medicine : a Journal of the British Diabetic Association·I W CampbellH F Woods
Jun 6, 2020·The Cochrane Database of Systematic Reviews·Filip GnesinBianca Hemmingsen
Oct 1, 2015·The Cochrane Database of Systematic Reviews·Antonio SaenzDavid Moher
Aug 5, 2017·Diabetologia·Clifford J Bailey
Mar 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·N R Waugh
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·A J Garber
Nov 1, 1995·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·R J Mahler
Nov 13, 2020·Frontiers in Pharmacology·Guadalupe Del Carmen Baeza-FloresVinicio Granados-Soto

Related Concepts

Insogen
Diabetes Mellitus
Diet
Glucophage

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.