Comparison of microfocus- and synchrotron X-ray tomography for the analysis of osteointegration around Ti6Al4V implants

European Cells & Materials
R BernhardtH Worch

Abstract

Micro-computed tomography (microCT) provides quantitative three-dimensional information of bone around titanium implants similar to classical histology. The study, based on an animal model, containing cuboid-shaped biofunctionalised Ti6Al4V implants with surrounding bone after 4 weeks, is performed using 3 microCT-systems with X-ray tubes, one synchrotron-radiation-based microCT-system (SRmicroCT), and classical histology. Although the spatial resolution of the microCT-systems is comparable, only the results of SRmicroCT agree with results of classical histology. The X-ray tube sources give rise to huge artefacts in the tomograms (interface scattering, beam hardening), which impaired the quantitative analysis of bone up to about 200microm from the implant surface. Due to the non-destructive character of microCT the specimens can be subsequently examined by classical histology without restriction. The quantitative comparison of bone formation uncovers the strong dependence of the newly formed bone from the selected slice. This implies the necessity of 3D analysis. SRmicroCT and classical histology prove that surface modifications of the titanium implant significantly influence the bone formation. Using SRmicroCT, the preparation...Continue Reading

Citations

Nov 8, 2006·Biotechnology and Bioengineering·Françoise PeyrinRoberta Martinetti
Mar 7, 2007·Calcified Tissue International·David CooperBenedikt Hallgrimsson
May 19, 2011·Journal of Dental Research·E CoutinhoB Van Meerbeek
Mar 20, 2012·The Journal of the Acoustical Society of America·Jacques RivièrePaul A Johnson
Feb 6, 2019·Frontiers in Bioengineering and Biotechnology·Sophie Le CannHanna Isaksson
May 8, 2007·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Bert MüllerPhilipp J Thurner
May 11, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Stefan VandewegheRyo Jimbo
Apr 28, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F Peyrin
Dec 17, 2011·Clinical Implant Dentistry and Related Research·Hamid SarveCarina B Johansson
Aug 15, 2014·Tissue Engineering. Part B, Reviews·Guenaelle BouetLaurence Vico
Oct 5, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Zihui LiDavide Ruffoni
Oct 22, 2016·Clinical Oral Investigations·Marcin KozakiewiczJerzy Sokołowski
Sep 3, 2020·Clinical Implant Dentistry and Related Research·Puria ParviniKathrin Becker
Feb 17, 2006·Physics in Medicine and Biology·A WagnerJ Mollenhauer
Feb 24, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Bernd StadlingerUwe Eckelt
Apr 1, 2016·Connective Tissue Research·Maiquan WangYunfeng Li
Jul 1, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·A De RanieriD R Sumner
Sep 26, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yankel GabetItai Bab
Jan 11, 2016·Journal of Biomedical Materials Research. Part a·Svetlana GorodzhaRoman A Surmenev
Mar 14, 2018·Journal of Microscopy·N ChicherovaP Cattin
Jun 15, 2007·Journal of Materials Science. Materials in Medicine·Manal M ShalabiJohn A Jansen
Sep 23, 2010·Journal of Dental Research·W ZouM V Swain
Sep 12, 2018·Journal of Periodontal & Implant Science·Jung-Yoo Chesaria ChoiIn-Sung Luke Yeo
Apr 23, 2011·Journal of Materials Science. Materials in Medicine·E BarilS A Hacking
May 11, 2020·Clinical Biomechanics·Hugues Albini LomamiGuillaume Haiat
Apr 22, 2015·Biomaterials·P KornU Scheler

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