PMID: 18203071Jan 19, 2008Paper

Comparison of middle-molecule clearance between convective control double high-flux hemodiafiltration and on-line hemodiafiltration

The International Journal of Artificial Organs
Khajohn TiranathanagulSomchai Eiam-Ong

Abstract

Hemodiafiltration (HDF) is now a well-recognized treatment modality for end-stage renal disease (ESRD) patients. It provides superior characteristics over conventional hemodialysis in many respects. On-line HDF, however, which has been mainly used in clinical practice, requires a special machine. Interestingly, the recently innovated convective-control double high-flux hemodiafiltration (CC-DHF) machine can provide HDF treatment with an adjustable convection rate by using the conventional volume-controlled dialysate flow hemodialysis machine in a modified way. The present study was conducted to compare the efficacy of CC-DHF compared to on-line HDF in terms of middle and small solute clearances in 12 stable, chronic hemodialysis patients who underwent hemodialysis three times a week for at least 6 months. The results showed that the beta 2-microglobulin (beta 2M) removal represented by the beta 2M clearance in CC-DHF was comparable to that in on-line HDF (112.4+/-17.0 vs. 119.4+/-15.5 ml/min respectively, NS). Also, the beta 2M reduction ratio in the CC-DHF group did not differ from the on-line HDF group (85.5+/-4.2% vs. 86.1+/-6.7%, NS). With regard to small solute clearances, the values of single-pool Kt/V and phosphate clear...Continue Reading

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Citations

Dec 1, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maria-Eleni RoumeliotiChristos P Argyropoulos
Oct 11, 2013·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Wiwat ChancharoenthanaSomchai Eiam-Ong
Mar 16, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Clark KensingerWilliam H Fissell
Sep 7, 2012·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Kyungsoo LeeH David Humes

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