PMID: 16508395Mar 2, 2006Paper

Comparison of minimum alveolar concentration between intravenous isoflurane lipid emulsion and inhaled isoflurane in dogs

Anesthesiology
Xiao-Lin YangJin Liu

Abstract

As in inhaled isoflurane anesthesia, when isoflurane lipid emulsion (ILE; 8%, vol/vol) is intravenously administered, the primary elimination route is through the lungs. This study was designed to determine the minimum alveolar concentration (MAC) and the time course of washout of isoflurane for intravenously infused ILE by monitoring end-tidal isoflurane concentration. Twelve healthy adult mongrel dogs were assigned randomly to an intravenous anesthesia group with 8% ILE or to an inhalation anesthesia group with isoflurane vapor. An up-and-down method and stimulation of tail clamping were used to determine MAC of 8% ILE by intravenous injection in the intravenous anesthesia group and MAC by the inhaled approach in the inhalation anesthesia group, respectively. Isoflurane concentration and partial pressure in end-tidal gas, femoral arterial blood, and jugular venous blood were measured simultaneously just before each tail clamping and during washout. The induction time in the intravenous anesthesia group (105 +/- 24 s) was shorter than that in the inhalation anesthesia group (378 +/- 102 s; P < 0.01). MAC of 8% ILE by intravenous injection (1.12 +/- 0.18%) was significantly less than MAC by the inhaled approach (1.38 +/- 0.16%;...Continue Reading

References

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Citations

Dec 12, 2012·Frontiers of Medicine·Cheng Zhou, Jin Liu
Feb 28, 2009·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Zhao-Yang HuJin Liu
Feb 28, 2009·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Jacob Raphael, Carl Lynch
Sep 28, 2012·British Journal of Anaesthesia·X-L YangX-H Jiang
Apr 27, 2012·TheScientificWorldJournal·David MacíasJosé M Ortiz de Urbina
Feb 12, 2009·Clinical and Experimental Pharmacology & Physiology·Zhao-Yang Hu, Jin Liu
Apr 2, 2010·Anesthesia and Analgesia·Zhuo LiGuo-Hua Li
Feb 2, 2013·International Journal of Medical Sciences·Zhenmeng WangWeifeng Yu
Jun 24, 2011·International Journal of Medical Sciences·Xin LvWei-Feng Yu
Jan 23, 2015·A & a Case Reports·Evi R SteenPatrick Wouters
Apr 23, 2013·Fundamental & Clinical Pharmacology·Zhao-Yang HuJin Liu
Oct 10, 2015·Veterinary Anaesthesia and Analgesia·Claudio C NataliniAnthony Nicholson
Jan 21, 2012·Anesthesiology·Evan D Kharasch
Apr 7, 2007·Anesthesiology·Evan D Kharasch
Nov 29, 2007·British Journal of Anaesthesia·Y-F ChaiQ-W Wang
Mar 18, 2017·Veterinary Anaesthesia and Analgesia·Claudio C NataliniRicardo Miyasaka de Almeida

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