Comparison of mitozantrone and epirubicin in advanced breast cancer

Clinical Oncology : a Journal of the Royal College of Radiologists
A M CookG J Rees

Abstract

Forty chemotherapy naive patients with metastatic or locally advanced breast cancer were treated in a randomized trial comparing mitozantrone 14 mg/m2 with epirubicin 75 mg/m2 given intravenously at 3-weekly intervals. There was a 40% (95% confidence interval (CI) 8-72; P = 0.013) higher partial response rate with epirubicin (11/18) than with mitozantrone (4/19). Epirubicin caused significantly more alopecia (difference 76%; 95% CI 57-96; P < 0.0001) and nausea/vomiting (difference = 38%; 95% CI 10-67; P = 0.01). Three patients who received long courses of epirubicin experienced cardiac failure; two were proved to have cardiomyopathy. The median survival for the epirubicin and mitozantrone groups were 9.5 and 8 months respectively. Thus, although epirubicin gave a higher response rate it also caused more toxicity.

References

May 1, 1987·European Journal of Cancer & Clinical Oncology·R Stuart-HarrisM H Tattersall
Jan 1, 1981·Cancer·A B MillerA Winkler

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Citations

Feb 21, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M ClemonsA Howell
May 20, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Lília R Cordeiro PedrosaGerben A Koning
Dec 11, 2008·Journal of the National Cancer Institute·Davide MauriJohn P A Ioannidis

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