Comparison of modified amino acids and standard amino acids in parenteral nutrition support of thermally injured patients

Critical Care Medicine
R O BrownR W Luther

Abstract

Twenty thermally injured patients who could not tolerate enteral nutrition support were randomized to receive parenteral nutrition (PN) with either modified amino acids (MAA) or standard amino acids (SAA). There was no significant difference between groups for age, sex, weight, percent BSA area burn, percent third-degree burn, or operative procedures. N balance (NB) was measured and serum was harvested for circulating fibronectin (Fn), somatomedin-C/insulin-like growth Factor I (Sm-C), prealbumin (PA), and retinol-binding protein (RBP) analysis on days 1, 4, 7, 14, 21, and 28 of PN. The patient groups received similar doses of PN for a similar number of days. Fn did not change significantly from baseline in either group and there was no significant difference between groups. Sm-C increased significantly from baseline at day 7 in the SAA group and in both groups on day 14, but there was no significant difference between groups. PA and RBP increased significantly from baseline on day 7 in the MAA group and in both groups on days 14, 21, and 28. RBP was significantly higher in the MAA group only on day 21, and there was no significant difference between groups for PA. NB increased significantly from baseline for all study days; ho...Continue Reading

Citations

Feb 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·F O AkenamiA Vaheri
Dec 24, 2014·The Cochrane Database of Systematic Reviews·Hannah B TanJason Wasiak
Jul 6, 2000·Revista do Hospital das Clínicas·A F DelgadoF R Carrazza
Aug 1, 1997·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·S KleinP Twomey

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