PMID: 8599884Jan 1, 1996Paper

Comparison of monocytes and B cells for activation of human T helper cell subsets

Clinical Immunology and Immunopathology
L BeckH L Spiegelberg

Abstract

Human rye grass allergen Lol p I-specific T helper cell clones of Thp, Th0, Th1 and Th2 subtype were activated with Lol p I and monocytes or B cells as antigen-presenting cells, and cell proliferation, interleukin (IL)-2, interferon-gamma, and IL-4 secretion were measured. Monocytes induced activation of T cell clones of all four T helper cell subsets and were usually more potent antigen-presenting cells than B cells. B cells and monocytes similarly induced proliferation and IL-4 secretion by Th2 clones, whereas B cells, in contrast to monocytes, only weakly activated Th1 clones. However, exceptions to this rule existed within each T helper cell subset suggesting that individual T cell clones, regardless of the subset to which they belong, may have quantitatively and/or qualitatively different requirements for secondary activation signals which are provided by the antigen-presenting cells. The data demonstrate that, in general, monocytes are more effective than B cells in activating human T cell clones of all subtypes and that B cells were efficient antigen-presenting cells only for Th2 cells. However, individual T cell clones of any given T helper cell subset vary with respect to their activation by monocytes or B cells.

Citations

Mar 16, 2000·Developmental and Comparative Immunology·R L CromieJ L Stanford
Jan 23, 2003·Annals of the New York Academy of Sciences·Lars Rogge
Jul 1, 2014·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Keiko YoshimotoTsutomu Takeuchi
Aug 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H KahlertH Fiebig

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