PMID: 6104822May 1, 1980Paper

Comparison of morphine, meperidine, anileridine, and alphaprodine on schedule-controlled responding and analgesia

Pharmacology, Biochemistry, and Behavior
J D Leander

Abstract

The effects of morphine, meperidine, alphaprodine, and anileridine were studied alone and in the presence of 1 mg/kg of naloxone in rats on level pressing under a fixed-ratio 20-response schedule of food presentation and on tail-withdrawal latency from warm water (55 degrees C) as a measure of analgesia. All four narcotics decreased rates of lever pressing and increased tail-withdrawal latencies. Naloxone antagonized the effects of all four narcotics on tail-withdrawal, but did not antagonize the rate-decreasing effect of meperidine on lever pressing. Naloxone shifted the morphine dose-effect for lever-pressing by a factor of 4-8; the alphaprodine dose-effect curve by a factor of 4-8; and the anileridine dose-effect curve by a factor of 2. These results strengthen the interpretation that meperidine's effect on schedule-controlled responding is not mediated by a narcotic action whereas the analgesic effect is. The results also suggest that anileridine has significant non-narcotic actions like meperidine.

References

Aug 1, 1978·Pharmacology, Biochemistry, and Behavior·J D Leander
Nov 10, 1976·Psychopharmacology·H E Shannon, S G Holtzman
Jun 1, 1977·European Journal of Pharmacology·R A HarrisE L Way
Aug 1, 1976·Pharmacology, Biochemistry, and Behavior·D E Mcmillan, J D Leander
Jan 1, 1974·Psychopharmacologia·L A DykstraL S Harris
Jul 20, 1964·Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie·L S HARRIS
Jan 1, 1965·Acta Anaesthesiologica Scandinavica·F F FOLDES, T A TORDA

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Citations

Oct 1, 1984·European Journal of Pharmacology·S HerlingJ H Woods
Dec 1, 1982·Neuropharmacology·P McCleary, J D Leander
Jul 1, 1981·Pharmacology, Biochemistry, and Behavior·J D Leander
Jun 1, 1982·Pharmacology, Biochemistry, and Behavior·J D Leander
Mar 1, 1982·Pharmacology, Biochemistry, and Behavior·J D Leander
Oct 1, 1989·Pharmacology, Biochemistry, and Behavior·M BartolettiM Babbini
Apr 22, 2005·The Journal of Pharmacology and Experimental Therapeutics·David A White, Stephen G Holtzman
Nov 1, 1981·Journal of the Experimental Analysis of Behavior·D M Thompson, J M Moerschbaecher

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