Comparison of mortality outcomes after radical prostatectomy versus radiotherapy in patients with localized prostate cancer: a population-based analysis

International Journal of Urology : Official Journal of the Japanese Urological Association
Firas AbdollahPierre I Karakiewicz

Abstract

To compare the mortality outcomes of radical prostatectomy and radiotherapy as treatment modalities for patients with localized prostate cancer. Our cohort consisted of 68 665 patients with localized prostate cancer, treated with radical prostatectomy or radiotherapy, between 1992 and 2005. Propensity-score matching was used to minimize potential bias related to treatment assignment. Competing-risks analyses tested the effect of treatment type on cancer-specific mortality, after accounting for other-cause mortality. All analyses were stratified according to prostate cancer risk groups, baseline Charlson Comorbidity Index and age. For patients treated with radical prostatectomy versus radiotherapy, the 10-year cancer-specific mortality rates were 1.4 versus 3.9% in low-intermediate risk prostate cancer and 6.8 versus 11.5% in high-risk prostate cancer, respectively. Rates were 2.4 versus 5.9% in patients with Charlson Comorbidity Index of 0, 2.4 versus 5.1% in patients with Charlson Comorbidity Index of 1, and 2.9 versus 5.2% in patients with Charlson Comorbidity Index of ≥2. Rates were 2.1 versus 5.0% in patients aged 65-69 years, 2.8 versus 5.5% in patients aged 70-74 years, and 2.9 versus 7.6% in patients aged 75-80 years (al...Continue Reading

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Citations

Nov 19, 2013·Journal of Comparative Effectiveness Research·Richard M HoffmanMichael J Barry
May 14, 2014·Nature Reviews. Urology·Christian BachAnthony Koupparis
Mar 5, 2014·Clinical Genitourinary Cancer·Fausto PetrelliSandro Barni
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Nov 2, 2015·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·M Soulié, L Salomon
Jan 3, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Firas AbdollahMaxine Sun
May 30, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Elisabetta Costantini, Luigi Mearini
Oct 26, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Drew MoghanakiMitchell Anscher
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