Comparison of mouse strains for susceptibility to styrene-induced hepatotoxicity and pneumotoxicity

Journal of Toxicology and Environmental Health
Gary P Carlson

Abstract

Styrene is known to cause both hepatotoxicity and pneumotoxicity in mice. Strain differences have been reported by other investigators suggesting that Swiss mice are less susceptible than non-Swiss mice to styrene-induced liver damage. In this study, A/J and C57BL/6 mice were found to be similar to non-Swiss albino (NSA) mice in susceptibility whereas CD-1 (Swiss) mice were more resistant to hepatotoxicity as assessed by serum sorbitol dehydrogenase levels and pneumotoxicity as determined by gamma-glutamyltranspeptidase and lactate dehydrogenase measurements in bronchoalveolar lavage fluid. Styrene was hepatotoxic in CD-1 mice treated with pyridine to induce CYP2E1. CYP2E1 apoprotein levels and p-nitrophenol hydroxylase activities in control and pyridine-induced mice were similar in the two strains. Hepatic and pulmonary microsomal preparations from both strains metabolized styrene to styrene oxide at similar rates. CD-1 mice were as susceptible as the NSA mice to the effects of styrene oxide. The data suggest that there are no differences in the bioactivation of styrene to styrene oxide or innate susceptibility to the active metabolite that would account for the differences between the CD-1 and NSA mice.

References

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Citations

Jan 27, 2000·Toxicology·M W Powley, G P Carlson
Nov 10, 2001·Toxicology Letters·M W Powley, G P Carlson
May 16, 2002·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Joshua T CohenKimberly Thompson
May 15, 2003·Journal of Toxicology and Environmental Health. Part a·Gary Carlson
Oct 16, 2007·Journal of Toxicology and Environmental Health. Part a·A NongK Krishnan
Mar 25, 2009·Journal of Toxicology and Environmental Health. Part a·Anna Meszka-JordanGary P Carlson
Apr 15, 2010·Journal of Toxicology and Environmental Health. Part a·Gary P Carlson
Nov 9, 2010·Journal of Toxicology and Environmental Health. Part a·Gary P Carlson
Jan 29, 2011·Journal of Toxicology and Environmental Health. Part a·Gary P Carlson
Jan 5, 2002·Drug Metabolism Reviews·I Linhart
Aug 8, 1997·Journal of Toxicology and Environmental Health·G P Carlson
Aug 12, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A O GamerB van Ravenzwaay
Jan 6, 2017·Laboratory animal research·Ji Eun KimDae Youn Hwang
Nov 18, 2000·Journal of Biochemical and Molecular Toxicology·M W Powley, G P Carlson
Jun 19, 2001·Journal of Applied Toxicology : JAT·G CruzanW R Brown
Aug 14, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Thomas Hill Iii, Rory B Conolly

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