Comparison of MRI and PET as Potential Surrogate Endpoints for Treatment Response After Stereotactic Radiosurgery in Patients With Brain Metastasis

AJR. American Journal of Roentgenology
Chong Hyun SuhS J Kim

Abstract

The purpose of this study is to compare the diagnostic performance of MRI and PET for differentiating tumor recurrence from radiation necrosis in patients with brain metastasis treated with stereotactic radiosurgery. The Ovid-Medline and Embase databases were searched up to November 11, 2017, to find relevant studies. Pooled sensitivity and specificity from entire included studies were obtained using hierarchic logistic regression modeling. Metaregression was performed. Twenty studies including 728 patients with 872 brain metastases were selected. MRI showed a pooled sensitivity of 84% (95% CI, 72-91%) and specificity of 88% (95% CI, 71-96%). PET showed a pooled sensitivity of 84% (95% CI, 78-88%) and specificity of 86% (95% CI, 81-90%). There were no statistically significant differences in the diagnostic performance of MRI and PET using indirect (p = 0.80) or direct (p = 0.48) comparisons. The diagnostic performance of advanced MRI was significantly higher than that of conventional MRI (p = 0.01). Advanced MRI (sensitivity, 86% [95% CI, 74-93%]; specificity, 95% [95% CI, 82-98%]) showed a significantly higher diagnostic performance than did PET (p < 0.01). All the included studies used perfusion MRI as an advanced MRI techniq...Continue Reading

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