PMID: 8950352Nov 4, 1996Paper

Comparison of mutagenic activity of bile between Chilean and Japanese female patients having cholelithiasis

Mutation Research
H ManoH Watanabe

Abstract

The mutagenic activity of bile was compared between Chilean and Japanese female patients having cholelithiasis by the Ames assay using Salmonella typhimurium tester strain TA98 in the presence of S9 mix with blue rayon adsorption technique. A reason for conducting the present investigation is that Chile and Japan have the highest mortality rates for the gallbladder cancer (GBC) in the world. Of 24 bile samples collected in Chile, 20 (83.3%) samples showed mutagenicity. In the case of Japanese bile, 21 (80.8%) of 26 and 5 (19.2%) of 26 cases were mutagenic in samples from high- and low-risk areas for GBC, respectively. Therefore, both the Chilean and the Japanese samples collected in high-risk areas showed higher mutagenic rates than the Japanese ones in a low-risk area, with a statistical significance (p < 0.001), chi-square test). The average number of revertant colonies were 128 +/- 92 (mean +/- SD), 62 +/- 14 and 66 +/- 13, respectively, when the blue rayon extracts of 200 microliters bile were applied to the Ames test. Thus, Chilean bile had a tendency to show a higher mutagenic activity than Japanese.

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Citations

Jan 1, 2003·Environmental Health and Preventive Medicine·Masaharu Yamamoto
Jun 12, 2010·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S V ShrikhandeA K Agarwal
Jun 6, 2009·Histopathology·Robert David Goldin, Juan Carlos Roa
Aug 27, 2009·Environmental and Molecular Mutagenesis·Patrícia Estevam dos SantosGisela de Aragão Umbuzeiro
Dec 21, 2005·Clinical Biochemistry·Yasuo TsuchiyaMasaharu Yamamoto
Oct 18, 2014·World Journal of Clinical Cases·Keita KaiKohji Miyazaki
Aug 10, 2004·Alimentary Pharmacology & Therapeutics·H MurataM Hori

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