Feb 28, 2016

Comparison of myelin water fraction values in periventricular white matter lesions between multiple sclerosis and neuromyelitis optica spectrum disorder

Multiple Sclerosis : Clinical and Laboratory Research
In Hye JeongHo Jin Kim

Abstract

Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are inflammatory autoimmune diseases of the central nervous system. We hypothesized that the degree of demyelination within lesions in MS and NMOSD would differ as the pathophysiology of the two diseases do. We used myelin water imaging to compare the myelin water fraction (MWF) in 106 periventricular white matter (PVWM) lesions in 27 MS patients and 51 PVWM lesions in 20 NMOSD patients. The MWF was significantly reduced in the MS compared with the NMOSD lesions, suggesting that myelin loss was more severe in MS than in NMOSD.

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Citations

Mentioned in this Paper

Periventricular White Matter
Myelin Sheath
Metal Working Fluid
Bulla
Myelin
Mass Spectrometry
Autoimmune Diseases
CNS Disorder
MS gene
Physiopathological

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