Comparison of myocardial contrast echocardiography derived myocardial perfusion reserve with invasive determination of coronary flow reserve

European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology
S Michelle BierigArthur J Labovitz

Abstract

Invasive measurements of coronary flow reserve (CFR) by Doppler flow wire are an established method for determining coronary blood flow physiology. Myocardial contrast echocardiography (MCE) is a potential non-invasive method for quantifying myocardial blood flow (MBF). However, few studies have compared MCE-derived myocardial perfusion reserve (MPR) with Doppler flow wire-derived CFR, measured simultaneously in human subjects. This study aimed to correlate MCE-derived MPR with Doppler flow wire-derived CFR. Ten patients with at least two angiographically normal coronary arteries underwent simultaneous invasive Doppler flow wire measurements and MCE imaging at rest and at peak hyperaemia. Hyperaemia was induced by intravenous adenosine infusion. Doppler-derived CFR was calculated as the ratio of hyperaemic to baseline average peak red blood cell velocity. MPR was calculated as the hyperaemic to baseline ratio of the following parameters: myocardial blood volume (MBV), myocardial microbubble velocity (MMV), and MBF. MCE was performed using real-time and triggered imaging with contrast infused intravenously by bolus and continuous methods. Regardless of whether the contrast was infused by bolus or continuous methods, Doppler flow...Continue Reading

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Citations

Apr 22, 2009·Cardiovascular Ultrasound·Petri GudmundssonRonnie B Willenheimer
Jun 19, 2009·Cardiovascular Ultrasound·Petri GudmundssonLennart Ljunggren
Dec 22, 2015·Expert Review of Cardiovascular Therapy·Anastasia VamvakidouRoxy Senior
Mar 24, 2010·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Brian Bridal LøgstrupKenneth Egstrup
Mar 10, 2017·Expert Review of Medical Devices·Piotr J SlomkaGuido Germano
Sep 18, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Boran KatunaricJulie K Freed
Sep 22, 2011·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Sahar S AbdelmoneimSharon L Mulvagh
Mar 27, 2010·Revista española de cardiología·Río Aguilar-TorresRicardo Vivancos-Delgado

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