Comparison of myocardial fibrosis quantification methods by cardiovascular magnetic resonance imaging for risk stratification of patients with suspected myocarditis

Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance
Christoph GräniRaymond Y Kwong

Abstract

Although the presence of late gadolinium enhancement (LGE) using cardiovascular magnetic resonance imaging (CMR) is a significant discriminator of events in patients with suspected myocarditis, no data are available on the optimal LGE quantification method. Six hundred seventy consecutive patients (48 ± 16 years, 59% male) with suspected myocarditis were enrolled between 2002 and 2015. We performed LGE quantitation using seven different signal intensity thresholding methods based either on 2, 3, 4, 5, 6, 7 standard deviations (SD) above remote myocardium or full width at half maximum (FWHM). In addition, a LGE visual presence score (LGE-VPS) (LGE present/absent in each segment) was assessed. For each of these methods, the strength of association of LGE results with major adverse cardiac events (MACE) was determined. Inter-and intra-rater variability using intraclass-correlation coefficient (ICC) was performed for all methods. Ninety-eight (15%) patients experienced a MACE at a medium follow-up of 4.7 years. LGE quantification by FWHM, 2- and 3-SD demonstrated univariable association with MACE (hazard ratio [HR] 1.05, 95% confidence interval [CI]:1.02-1.08, p = 0.001; HR 1.02, 95%CI:1.00-1.04; p = 0.001; HR 1.02, 95%CI: 1.00-1.0...Continue Reading

Associated Clinical Trials

Mar 20, 2018·Raymond Y. Kwong, MD

References

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Citations

Nov 2, 2019·AJR. American Journal of Roentgenology·Qian TaoRob J van der Geest
Aug 30, 2020·European Heart Journal·Antonio PellicciaUNKNOWN ESC Scientific Document Group
Mar 5, 2020·European Journal of Preventive Cardiology·Martin HalleCarsten Tschöpe
May 21, 2020·The American Journal of Tropical Medicine and Hygiene·Martha Valéria Tavares PinheiroAndréa Silvestre de Sousa
Jan 14, 2021·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Warren J Manning
Jun 17, 2019·JACC. Cardiovascular Imaging·Christian EichhornChristoph Gräni
Feb 28, 2021·European Journal of Preventive Cardiology·Bernhard SchwaabRona Reibis
Feb 22, 2021·European Journal of Preventive Cardiology·Martin HalleCarsten Tschöpe
Feb 26, 2021·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Hui WangLei Xu
May 24, 2021·JACC. Cardiovascular Imaging·Sumit GuptaRaymond Y Kwong
Oct 9, 2021·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Daniel E ClarkJonathan H Soslow

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Methods Mentioned

BETA
biopsies

Software Mentioned

SAS
SPSS
MASS

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