Comparison of myocardial transmural perfusion gradient by magnetic resonance imaging to fractional flow reserve in patients with suspected coronary artery disease

The American Journal of Cardiology
Jingwei PanMeng Wei

Abstract

The goal of this study was to evaluate the diagnostic accuracy of transmural perfusion gradient (TPG) and transmural perfusion gradient reserve (TPGR) with 3.0 T cardiac magnetic resonance (CMR) against invasively determined fractional flow reserve (FFR) to detect coronary artery stenosis. Quantitative analysis of myocardial perfusion with CMR to diagnosis coronary artery disease (CAD) has been widely accepted. However, traditional transmural myocardial perfusion analysis with CMR neglects that endocardium is more vulnerable to ischemia than epicardium. TPG and TPGR can take the inhomogenous perfusion impairment into account and be more sensitive and specific for diagnosis of CAD. In this study, 71 patients (57 men, age 60.1 ± 6.4 years) with known or suspected CAD referred for invasive angiography study underwent rest and adenosine-induced stress CMR perfusion imaging scan. FFR was attempted to be measured in all major epicardial coronary arteries. FFR ≤0.75 was regarded to indicate a hemodynamic significant coronary lesion. A TPG ≤0.85 predicted significant CAD with sensitivity and specificity of 74.55% and 83.65%, respectively. Sensitivity and specificity of TPGR ≤0.81 were 90.91% and 89.94%, respectively. Area under the rec...Continue Reading

References

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Citations

Dec 15, 2015·Journal of Molecular and Cellular Cardiology·Hicham LabaziS Jamal Mustafa
Nov 28, 2017·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·R van DijkM Oudkerk
Sep 22, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Roberto SciagràRaffaella Calabretta
Nov 30, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Kartik GuptaNavkaranbir S Bajaj
Aug 9, 2020·Circulation. Cardiovascular Imaging·Judith L MeadowsRobert Soufer
Jan 10, 2018·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·P GargS Plein

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