Comparison of nail lacquer clobetasol efficacy at 0.05%, 1% and 8% in nail psoriasis treatment: prospective, controlled and randomized pilot study

Anais Brasileiros De Dermatologia
Robertha Carvalho NakamuraAndreia Pizarro Leverone

Abstract

Nail psoriasis may affect up to 90% of patients with psoriasis in the course of the disease throughout their lives and it is often a therapeutic challenge to dermatologists. Topical treatments described in the literature have demonstrated variable efficacy, and unsatisfactory results have been associated to inefficient penetration of the active ingredient into the nail plate and proximal nail fold. Recently the use of clobetasol on nail lacquer vehicle has been suggested, with satisfactory results and no side effects. To determine the efficacy and safety of clobetasol in nail lacquer vehicle in three concentrations (0.05%, 1% and 8%) in patients with nail psoriasis. Prospective, controlled, randomized pilot study in fifteen patients with nail bed and/or nail matrix psoriasis in both hands, subdivided into three groups: A(0.05% clobetasol nail lacquer), B(1% clobetasol nail lacquer) and C(8% clobetasol nail lacquer). All groups used clobetasol nail lacquer on the left hand and base coat nail lacquer as control on the right, twice a week for 16 weeks. Clinical evaluation was done by photographic records and the NAPSI score of both treated and control hands, as well as modified NAPSI score of the most affected nail of the treated ...Continue Reading

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Citations

Apr 5, 2016·Drugs·Marcel C Pasch
Oct 18, 2013·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Mohamad Goldust, Ramin Raghifar
Mar 18, 2016·Anais Brasileiros De Dermatologia·Suze Aparecida da SilvaPaulo Eduardo Neves Ferreira Velho
Apr 29, 2014·Anais Brasileiros De Dermatologia·Karen Regina Rosso SchonsOdirlei André Monticielo
Jul 20, 2017·The British Journal of Dermatology·C I BusardP I Spuls
Mar 1, 2018·American Journal of Clinical Dermatology·Danielle R McClanahan, Joseph C English
Jun 14, 2013·Dermatology Research and Practice·Yasemin Oram, A Deniz Akkaya
Apr 3, 2020·International Journal of Dermatology·Purva Thatai, Arshad B Khan
Mar 23, 2021·Dermatologic Clinics·Jose W Ricardo, Shari R Lipner
May 13, 2021·Dermatology and Therapy·Edward HadelerWilson Liao

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