PMID: 9435939Jan 1, 1997Paper

Comparison of native xenogeneic and allogeneic bone morphogenetic proteins in the sheep skull defect assay model

Annales Chirurgiae Et Gynaecologiae
V V Viljanen, T S Lindholm

Abstract

The purpose of this study was to determine, if there is any difference in the osteoinductive response between xenogeneic and allogeneic bone morphogenetic protein (BMP) in the skull defect assay model. The skull samples of two experimental series were chosen for uniform radiomorphometric measurement. In the xenogeneic BMP group (X-group), 52 mg of native moose (Alces alces) BMP (mBMP) was implanted in six 22-mm sheep midline skull defects, and in the allogeneic BMP (A-group), 8 mg of native sheep BMP (sBMP) was used in six same size parietal skull defects. The formation of new bone was confirmed histologically and the quantity of it was measured radiomorphometrically at 16 weeks after implantation from the standardized radiographs using a common flatbed scanner and image processing software, the mean grey scale intensity (radiopacity) multiplied by the original defect area giving the new bone volume. This was divided by the milligram amount of implanted BMP to get the value for comparison of BMP activities. The control defects in both groups, implanted with 13 mg of type IV collagen, showed that the defects did not heal spontaneously during the follow-up time. In the X-group, the healing percentage was 92.4 +/- 3.0%, the calcul...Continue Reading

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