Comparison of navigator-gated and breath-held image acquisition techniques for multi-echo quantitative dixon imaging of the liver in children and young adults

Abdominal Radiology
Leah A GilliganAndrew T Trout

Abstract

Acquired over a breath hold, multi-echo Dixon (mDixon) magnetic resonance imaging (MRI) of the liver can be used to quantify proton density fat fraction (PDFF) and iron-related signal decay. However, young, obese, and co-morbid patients may have limited breath holding capacity and could benefit from a motion-robust mDixon acquisition. The purpose of this study was to compare hepatic PDFF and R2* values between navigator-gated and breath-held mDixon MRI acquisition techniques in children and young adults with suspected liver disease. This retrospective study was institutional review board-approved with a waiver of informed consent. Patients who underwent liver MRI with breath-held and navigator-gated mDixon sequences between January 2017 and July 2018 were included. One reviewer, blinded to sequence, measured PDFF and R2* on four images from each sequence. Another blinded reviewer graded respiratory motion (5-point Likert scale). Pearson correlation (r), Lin's concordance coefficients (rc), and Bland-Altman analyses were used to assess agreement between techniques. Frequency of clinically limiting motion (score ≥ 3) was compared with Fisher's exact test. Forty-two patients were included (15 female, 27 male; mean age: 15.7 ± 4.6 ...Continue Reading

References

Oct 1, 1984·Radiology·W T Dixon
Oct 4, 2006·Pediatrics·Jeffrey B SchwimmerCynthia Behling
Apr 7, 2007·Current Opinion in Hematology·John C Wood
May 28, 2009·Journal of Magnetic Resonance Imaging : JMRI·Scott B ReederJean H Brittain
Jul 20, 2011·Journal of Magnetic Resonance Imaging : JMRI·Geraldine H KangClaude B Sirlin
May 23, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mazen NoureddinRohit Loomba
Sep 21, 2013·Diagnostic and Interventional Radiology : Official Journal of the Turkish Society of Radiology·Puneet SharmaDiego R Martin
Nov 5, 2013·Magnetic Resonance Imaging Clinics of North America·Alexander J TowbinDaniel J Podberesky
Dec 9, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rohit LoombaUNKNOWN San Diego Integrated NAFLD Research Consortium (SINC)
Apr 2, 2015·Journal of Magnetic Resonance Imaging : JMRI·Utaroh MotosugiScott B Reeder
Apr 8, 2015·Journal of Magnetic Resonance Imaging : JMRI·Kevin A ZandClaude B Sirlin
Jul 15, 2017·AJR. American Journal of Roentgenology·Camilo A CampoScott B Reeder
Oct 14, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael S MiddletonUNKNOWN NASH Clinical Research Network

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Citations

Apr 25, 2021·Abdominal Radiology·Alexander C BoyarkoAndrew T Trout
Sep 28, 2020·Seminars in Ultrasound, CT, and MR·Amirkasra MojtahedTakeshi Yokoo

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