Abstract
To compare the efficacy and tolerability of nebulized adrenaline and terbutaline in acute severe asthma. Prospective pilot randomized double-blind cross-over trial. Emergency department of a university hospital. Thirty-eight patients admitted with severe acute asthma. Each patient received adrenaline (3 mg) and terbutaline (5 mg) nebulizations over 20 min in randomized order. Additional treatment comprised methylprednisolone, intravenous hydration, and oxygen. The efficacy and tolerability of the two drugs were evaluated at the end of each nebulization as well as potential synergistic effects. Eighteen patients received adrenaline first, and 20 received terbutaline first. Peak expiratory flow (PEF) improved significantly in both groups after the first nebulization (from 157 L/min +/- 111 L/min to 199 L/min +/- 134 L/min with adrenaline, P <.01; and from 142 L/min +/- 65 L/min to 193 L/min +/- 181 L/min with terbutaline, P <.01). Both drugs induced a significant decrease in respiratory frequency. The improvement in PaO2 was only significant with terbutaline. Respiratory frequency, PEF and PaO2 were not improved by the second nebulization. No adverse effects were observed. Adrenaline nebulization was as effective and as well tole...Continue Reading
References
Apr 1, 1989·Thorax·E BallesterR Rodriguez-Roisin
Apr 1, 1988·Annals of Emergency Medicine·R CydulkaJ Mathews
Jun 29, 1981·Life Sciences·N GrundströmJ E Wikberg
Jan 1, 1995·Intensive Care Medicine·F AbrougS Bouchoucha
Jun 1, 1994·American Journal of Respiratory and Critical Care Medicine·S SalmeronG Simonneau
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·G J Rodrigo, C Rodrigo
Citations
Jan 26, 2011·Critical Care Medicine·Matthias LangePerenlei Enkhbaatar
Sep 8, 2009·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Knut Øymar, Thomas Halvorsen
Sep 13, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Pritish MondalLeslie Hendeles
May 8, 2015·Lung India : Official Organ of Indian Chest Society·Ritesh AgarwalSubhash Varma
Jan 31, 2016·Intensive Care Medicine·Fekri AbrougLamia Ouanes-Besbes
Mar 8, 2011·Journal of Critical Care·Sunghoon ParkKi-Suck Jung
Feb 24, 2006·The American Journal of Emergency Medicine·Gustavo J Rodrigo, Luis J Nannini
Jul 14, 2007·CJEM·Kristopher Wiebe, Brian H Rowe
Sep 13, 2014·Clinical Reviews in Allergy & Immunology·Timothy E AlbertsonAndrew L Chan
Nov 2, 2013·Clinical Reviews in Allergy & Immunology·T E AlbertsonS Louie
Jan 31, 2009·Journal of Burn Care & Research : Official Publication of the American Burn Association·Perenlei EnkhbaatarDaniel L Traber
Jun 18, 2014·The Cochrane Database of Systematic Reviews·Anne M Gadomski, Melissa B Scribani
Aug 27, 2019·Pediatric Emergency Care·Larry B Mellick, Juan Gonzalez
Jan 1, 2013·World Journal of Emergency Medicine·Joseph P WoodChristopher Lipinski
Mar 31, 2020·The American Journal of Emergency Medicine·Brit LongMichael Gottlieb
Jul 12, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Andrew Menzies-GowDavid J Jackson
Oct 2, 2021·Thorax·Christina BaggottJames Fingleton