Comparison of neointimal formation in polymer-free paclitaxel stents versus stainless stents (from the ASPECT and ELUTES randomized clinical trials)

The American Journal of Cardiology
Grzegorz L KałuzaAlbert E Raizner

Abstract

The investigators examined 326 pairs of angiograms from 2 randomized dose-finding (0.2 to 3.1 microg paclitaxel/mm(2) of stent surface area) clinical trials of polymer-free paclitaxel-eluting stents in de novo lesions (the ASian Paclitaxel-Eluting stent Clinical Trial [ASPECT] and the European evaLUation of Taxol Eluting Stent [ELUTES]). A dose-dependent effect was observed: the largest dose of paclitaxel in the 2 trials resulted in a significantly larger proportion of lesions at follow-up with <10% diameter stenosis (54% vs 16%, p = 0.00012 in ASPECT; 53% vs 21%, p = 0.013 in ELUTES) and with minimal luminal diameter located outside the stent compared with control stents (62% vs 20% in ASPECT, 48% vs 18% in ELUTES; p <0.05). Also, significantly shorter lesion lengths at 6-month follow-up were observed for the doses of 0.7 to 3.1 microg/mm(2) (p <0.03) relative to their respective lengths before the procedure compared with control stents.

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Citations

Mar 8, 2008·Journal of Biomaterials Science. Polymer Edition·G-X WangR Guidoin
Aug 13, 2015·Annals of Biomedical Engineering·Marco G MennuniGiulio G Stefanini
Aug 1, 2008·Kidney International·Li LiAlfred K Cheung
Jan 4, 2012·Pharmacology & Therapeutics·Michail I PapafaklisLampros K Michalis
Apr 12, 2005·The Journal of Surgical Research·Yoshimasa MizunoHirofumi Takemura
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Mar 30, 2005·International Anesthesiology Clinics·Kyung W Park
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Feb 3, 2016·Cardiovascular Engineering and Technology·Aimée SakesPaul Breedveld
Jun 19, 2007·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·L-S LiuR Guidoin

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