PMID: 3755812Jul 24, 1986Paper

Comparison of neuropeptide Y immunoreactivity in hypothalamic and brainstem nuclei of young and mature spontaneously hypertensive and normotensive Wistar-Kyoto rats

Neuroscience Letters
C MaccarroneE L Conway

Abstract

The concentration of neuropeptide Y immunoreactivity (NPY-ir) was measured in 8 hypothalamic and 5 brainstem nuclei of 6- and 14-week-old spontaneously hypertensive (SH) and Wistar-Kyoto (WKY) rats. Strain differences were observed in 3 hypothalamic nuclei and age-dependent changes occurred in 3 hypothalamic and 2 brainstem nuclei. In both the ventromedial hypothalamic nucleus and locus coeruleus the observed change in NPY-ir with age in SH rats was significantly different to the change observed in the WKY. These strain- and age-related differences in NPY-ir may be of relevance in the development of hypertension in the SH rat.

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Citations

Aug 11, 1987·Brain Research·T NakajimaK Nakamura
Jan 1, 1989·Brain Research. Brain Research Reviews·S M Gardiner, T Bennett
Jan 1, 1996·Brain Research. Molecular Brain Research·K J McLeanA J Lawrence
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·C WahlestedtE Widerlöv
Sep 1, 1989·Brain Research Bulletin·J A AguirreS González-Barón
May 30, 2002·Neuroscience and Biobehavioral Reviews·Ants KaskRémi Quirion
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·E L ConwayW J Louis
Oct 3, 2001·Physiological Reviews·H E de Wardener

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