PMID: 9171163May 1, 1997Paper

Comparison of neurotoxicity following repeated administration of l-dopa, d-dopa and dopamine to embryonic mesencephalic dopamine neurons in cultures derived from Fisher 344 and Sprague-Dawley donors

Cell Transplantation
T AlexanderKathy Steece-Collier

Abstract

Levodopa is the most efficacious and widely used symptomatic drug for Parkinson's disease (PD). There is currently, however, a great deal of interest focused on the possibility that levodopa-induced increases in dopamine (DA) turnover may increase oxidative damage derived from the breakdown of DA. Increased oxidative damage following levodopa may contribute to the progressive degeneration of remaining host nigral neurons as well as interfere with development and function of embryonic nigral neurons in neural grafting trials. There is abundant evidence that levodopa is toxic to embryonic nigral DA neurons in both cell culture and neural grafting models. These findings have prompted a number of studies on mechanisms of levodopa toxicity to identify effective means of ameliorating potential oxidative stress related to levodopa in PD. In the current study we have utilized cultures of embryonic nigral DA neurons to address the fundamental question of whether levodopa-induced toxicity is related to DA production or whether dopa itself contributes to cell death. We compared the degree of nigral DA cell death following chronic administration of: 1) levodopa (e.g.: l-dopa); 2) its less active stereoisomer d-dopa; and 3) DA. We examined ...Continue Reading

Citations

Oct 18, 2006·Clinical and Experimental Pharmacology & Physiology·Mei WuYong-Xiang Wang
Apr 8, 2010·Rejuvenation Research·Donald Eugene RedmondJohn R Sladek
Apr 5, 2002·Biochemical Pharmacology·Bärbel Eppler, Ralph Dawson
Dec 3, 1999·Brain Research. Molecular Brain Research·D M Kuhn, R E Arthur
Apr 3, 2007·Journal of Neural Transmission·A W CoppusC M van Duijn

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