PMID: 11324576Apr 28, 2001Paper

Comparison of NMDA and non-NMDA receptor antagonists-induced inhibition in hindpaw withdrawal response to noxious thermal stimulation

Sheng li xue bao : [Acta physiologica Sinica]
Y S Shu, Z Q Zhao

Abstract

In our previous electrophysiological study, it was shown that NMDA receptors are predominantely involved in the transmission of nociceptive cutaneous afferents, whereas non-NMDA receptors are mainly concerned with the transmission of nociceptive muscular afferents. In the present investigation, the effects of NMDA and non-NMDA receptor antagonists were tested in rat hindpaw withdrawal response to noxious thermal stimulation. Intrathecal application of non-NMDA receptor antagonist 1 nmol/L DNQX (6,7-dinitroquinoxaline-2,3(1H, 4H)-dione) had no effect on paw withdrawal latencies (PWL), but NMDA receptor antagonist 1 nmol/L APV [(+/-) 2-amino-5-phosphonovalerate)] significantly prolonged PWL (P < 0.05). Both APV and DNQX at 10 nmol/L significantly increased PWL with the former agent being more potent. The results further support that both NMDA and non-NMDA receptors are involved in the transmission of spinal nociception, with the former being more preferentially involved in the transmission of nociceptive information from the skin.

Related Concepts

Related Feeds

Anti-N-Methyl-D-Aspartate Receptor Encephalitis

Anti-N-Methyl-D-Aspartate (NMDA) receptor encephalitis is a form of of brain inflammation due to antibodies against NMDA receptors. Discover the latest research on anti-NMDA receptor encephalitis here.