Comparison of non-invasive measures of cholinergic and allergic airway responsiveness in rats

Acta Physiologica
T GlaabHeinz Gerd Hoymann

Abstract

Non-invasive analysis of tidal expiratory flow parameters such as Tme/TE (time needed to reach peak expiratory flow divided by total expiratory time) or midexpiratory tidal flow (EF50) has been shown useful for phenotypic characterization of lung function in humans and animal models. In this study, we aimed to compare the utility of two non-invasive measures, EF50 and Tme/TE, to monitor bronchoconstriction to inhaled cholinergic and allergic challenges in Brown-Norway rats. Non-invasive measurements of Tme/TE and EF50 were paralleled by invasive recordings of Tme/TE, EF50 and pulmonary conductance (GL). First, dose-response studies with acetylcholine were performed in naive rats, showing that EF50 better than Tme/TE reflected the dose-related changes as observed with the classical invasive outcome parameter GL. The subsequent determination of allergen-specific early airway responsiveness (EAR) showed that ovalbumin-sensitized and -challenged rats exhibited airway inflammation and allergen-specific EAR. Again, EF50 was more sensitive than Tme/TE in detecting the allergen-specific EAR recorded with invasive and non-invasive lung function methods and agreed well with classical GL measurements. We conclude that non-invasive assessm...Continue Reading

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Citations

Jan 14, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Einat KodeshGregory R Adams
Sep 23, 2006·American Journal of Respiratory Cell and Molecular Biology·Irina KouznetsovaWerner Hoffmann
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Jun 27, 2015·PloS One·Vineet D MenacheryMartin T Ferris
May 4, 2007·Current Opinion in Pharmacology·Jörg Köhl, Marsha Wills-Karp

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