PMID: 867336Apr 1, 1977Paper

Comparison of occlusion pressure and ventilatory responses

Thorax
D H LedererN S Cherniack

Abstract

The airway pressure 100 msec after the onset of an inspiratory effort against a closed airway (P100, occlusion pressure) is theoretically a more accurate index of respiratory neuron motor output than ventilation. Occlusion pressure and ventilation responses to hypercapnia were compared in repeated trials in 10 normal subjects while in the seated and supine positions. During progressive hypercapnia changes in P100 were also compared to changes in tidal volume and inspiratory airflow. These studies show that occlusion pressure increases linearly with hypercapnia in both sitting and supine subjects. Changing from the seated to the supine position, or vice versa, had no significant effect on either ventilation or occlusion pressure responses to CO2. Correlations between P100 and ventilation or airflow rate were significantly higher than correlations between P100 and tidal volume or breathing frequency. Intermittent random airway occlusion had no effect on either ventilation or pattern of breathing during hypercapnia. Occlusion pressure responses were no less variable than ventilation responses in groups of subjects whether studied seated or supine. However, maintenance of a constant moderate breathing frequency (20 breaths per minu...Continue Reading

References

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Citations

Jan 1, 1988·European Journal of Applied Physiology and Occupational Physiology·A GratasP Rochcongar
Oct 13, 2009·Lung·Ann M SpungenF Dennis McCool
Feb 1, 1979·Respiration Physiology·M D AltoseN S Cherniack
Mar 1, 1983·Respiration Physiology·C M Hesser, F Lind
Oct 1, 1984·Respiration Physiology·S E MannixE E Davies
Jun 1, 1989·Archives of Disease in Childhood·Y A ParksH Simpson
Feb 1, 1992·The American Review of Respiratory Disease·T D MurphyD E Woodrum
Jan 1, 1992·Intensive Care Medicine·M J Tobin
Dec 29, 2009·Respiratory Physiology & Neurobiology·Dennis JensenMichael E Tschakovsky
Jul 31, 1998·Archives of Physical Medicine and Rehabilitation·K H LinY H Wang
Sep 15, 2019·Annals of Intensive Care·François BeloncleJean-Christophe Richard

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