PMID: 867336Apr 1, 1977Paper

Comparison of occlusion pressure and ventilatory responses

D H LedererN S Cherniack


The airway pressure 100 msec after the onset of an inspiratory effort against a closed airway (P100, occlusion pressure) is theoretically a more accurate index of respiratory neuron motor output than ventilation. Occlusion pressure and ventilation responses to hypercapnia were compared in repeated trials in 10 normal subjects while in the seated and supine positions. During progressive hypercapnia changes in P100 were also compared to changes in tidal volume and inspiratory airflow. These studies show that occlusion pressure increases linearly with hypercapnia in both sitting and supine subjects. Changing from the seated to the supine position, or vice versa, had no significant effect on either ventilation or occlusion pressure responses to CO2. Correlations between P100 and ventilation or airflow rate were significantly higher than correlations between P100 and tidal volume or breathing frequency. Intermittent random airway occlusion had no effect on either ventilation or pattern of breathing during hypercapnia. Occlusion pressure responses were no less variable than ventilation responses in groups of subjects whether studied seated or supine. However, maintenance of a constant moderate breathing frequency (20 breaths per minu...Continue Reading


Mar 1, 1976·Journal of Applied Physiology·M D AltoseA P Fishman
Mar 1, 1976·Journal of Applied Physiology·S G KelsenA P Fishman
Jun 1, 1975·Journal of Applied Physiology·C A HirshmanJ V Weil
Mar 1, 1975·Respiration Physiology·W A WhitelawJ Milic-Emili
Sep 1, 1973·Journal of Applied Physiology·A E GrassinoJ M Tyler
Oct 1, 1974·Journal of Applied Physiology·A S RebuckL D Pengelly
Aug 1, 1973·Journal of Applied Physiology·M J EvanichR V Lourenço
Oct 1, 1973·Journal of Applied Physiology·M M GrunsteinJ Milic-Emili
Feb 1, 1967·Australasian Annals of Medicine·D J Read
Nov 1, 1956·The Journal of Clinical Investigation·R M CHERNIACK, D P SNIDAL
May 1, 1960·The Journal of Clinical Investigation·D BRODOVSKYR M CHERNIACK
Sep 1, 1959·Journal of Applied Physiology·F ELDRIDGE, J M DAVIS
Mar 1, 1965·Acta Physiologica Scandinavica·M CORDA VON EULER
May 1, 1963·Journal of Applied Physiology·J Milic-Emili, J M Tyler


Jan 1, 1988·European Journal of Applied Physiology and Occupational Physiology·A GratasP Rochcongar
Oct 13, 2009·Lung·Ann M SpungenF Dennis McCool
Feb 1, 1979·Respiration Physiology·M D AltoseN S Cherniack
Mar 1, 1983·Respiration Physiology·C M Hesser, F Lind
Oct 1, 1984·Respiration Physiology·S E MannixE E Davies
Jun 1, 1989·Archives of Disease in Childhood·Y A ParksH Simpson
Feb 1, 1992·The American Review of Respiratory Disease·T D MurphyD E Woodrum
Jan 1, 1992·Intensive Care Medicine·M J Tobin
Dec 29, 2009·Respiratory Physiology & Neurobiology·Dennis JensenMichael E Tschakovsky
Jul 31, 1998·Archives of Physical Medicine and Rehabilitation·K H LinY H Wang
Sep 15, 2019·Annals of Intensive Care·François BeloncleJean-Christophe Richard

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.