Abstract
To compare the ocular hypotensive effect and safety of brinzolamide and timolol added to latanoprost monotherapy. In prospective randomized fashion, we evaluated the ocular hypotensive effect and safety of brinzolamide or timolol in 1 eye of 32 patients with primary open-angle glaucoma, normal-tension glaucoma, or ocular hypertension who had been treated with latanoprost for more than 1 month. Intraocular pressure (IOP), blood pressure, and pulse were measured before and at 4, 8, and 12 weeks. Corneal endothelial cell density was measured at baseline and at 12 weeks. The IOP was 17.8+/-1.7 mm Hg (mean+/-SD) before the addition of brinzolamide (n=15) and 15.7+/-2.1 mm Hg at 12 weeks (P<0.01). In comparison, the IOP was 18.5+/-3.7 mm Hg before the addition of timolol (n=15) and 15.8+/-3.2 mm Hg at 12 weeks (P<0.01). Both brinzolamide and timolol significantly decreased IOP at 12 weeks, by a mean of 2.0 mm Hg and mean 2.7 mm Hg, respectively, and were more effective than latanoprost alone (P<0.01), but there were no significant differences between the drugs and no significant differences in corneal endothelial cell density and blood pressure before and after addition of either drug. At 12 weeks, pulse was decreased in patients rec...Continue Reading
References
Jan 1, 1996·Ophthalmology·P Watson, J Stjernschantz
Jan 1, 1996·Ophthalmology·C B Camras
Apr 29, 1998·Journal of Glaucoma·G Kobelt-NguyenA Alm
Aug 26, 1998·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M Diestelhorst, B Almegård
Sep 23, 1998·American Journal of Ophthalmology·L H Silver
Apr 28, 1999·American Journal of Ophthalmology·A KonowalR J Epstein
Feb 22, 2000·American Journal of Ophthalmology·W F March, K I Ochsner
Sep 18, 2001·Journal of Glaucoma·A PetounisN Dimitrakoulias
Jul 6, 2002·Archives of Ophthalmology·Eve J HigginbothamUNKNOWN Fixed Combination Investigative Group
Dec 18, 2002·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Norbert Pfeiffer, UNKNOWN European Latanoprost Fixed Combination Study Group
May 10, 2003·Japanese Journal of Ophthalmology·Kenji InoueShiro Amano
Sep 24, 2004·Current Medical Research and Opinion·J M Martinez-de-la-CasaJ Garcia-Sanchez
May 19, 2005·Current Medical Research and Opinion·Nobuyuki ShojiKimiya Shimizu
Nov 3, 2005·Ophthalmology·Michael DiestelhorstUNKNOWN European-Canadian Latanoprost Fixed Combination Study Group
Nov 1, 2006·Ophthalmology·Michael Diestelhorst, UNKNOWN European-Canadian Latanoprost Fixed Combination Study Group
Citations
Apr 19, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Norbert Pfeiffer, UNKNOWN TATS (Travatan Adjunctive Treatment Study) group
Jan 31, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Hiroshi Kobayashi
Feb 2, 2010·Biological & Pharmaceutical Bulletin·Ayako SugimotoYukio Ono
Jun 14, 2012·Clinical Ophthalmology·Kenji InoueGoji Tomita
Sep 15, 2009·Clinical Ophthalmology·Makoto Ishikawa, Takeshi Yoshitomi
Jun 10, 2011·Current Medical Research and Opinion·James F T Li Yim, Donald M Montgomery
Jan 23, 2009·Ophthalmology·John H K LiuRobert N Weinreb
Jul 8, 2016·Advances in Therapy·Tadashi NakanoMasayuki Tatemichi
Apr 14, 2016·The Open Ophthalmology Journal·Mitsuhiro ImasawaKenji Kashiwagi
Jul 22, 2009·Expert Opinion on Pharmacotherapy·Gábor HollóMurat Irkec
Jul 12, 2019·Frontiers in Pharmacology·Yuanzhi LiuYilan Huang
Oct 27, 2020·Journal of Glaucoma·Tony RealiniMalik Y Kahook