Comparison of ocular hypotensive effect and safety of brinzolamide and timolol added to latanoprost

Journal of Glaucoma
Katsuya MiuraYukitaka Uji

Abstract

To compare the ocular hypotensive effect and safety of brinzolamide and timolol added to latanoprost monotherapy. In prospective randomized fashion, we evaluated the ocular hypotensive effect and safety of brinzolamide or timolol in 1 eye of 32 patients with primary open-angle glaucoma, normal-tension glaucoma, or ocular hypertension who had been treated with latanoprost for more than 1 month. Intraocular pressure (IOP), blood pressure, and pulse were measured before and at 4, 8, and 12 weeks. Corneal endothelial cell density was measured at baseline and at 12 weeks. The IOP was 17.8+/-1.7 mm Hg (mean+/-SD) before the addition of brinzolamide (n=15) and 15.7+/-2.1 mm Hg at 12 weeks (P<0.01). In comparison, the IOP was 18.5+/-3.7 mm Hg before the addition of timolol (n=15) and 15.8+/-3.2 mm Hg at 12 weeks (P<0.01). Both brinzolamide and timolol significantly decreased IOP at 12 weeks, by a mean of 2.0 mm Hg and mean 2.7 mm Hg, respectively, and were more effective than latanoprost alone (P<0.01), but there were no significant differences between the drugs and no significant differences in corneal endothelial cell density and blood pressure before and after addition of either drug. At 12 weeks, pulse was decreased in patients rec...Continue Reading

References

Aug 26, 1998·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M Diestelhorst, B Almegård
Apr 28, 1999·American Journal of Ophthalmology·A KonowalR J Epstein
Jul 6, 2002·Archives of Ophthalmology·Eve J HigginbothamUNKNOWN Fixed Combination Investigative Group
Dec 18, 2002·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Norbert Pfeiffer, UNKNOWN European Latanoprost Fixed Combination Study Group
May 10, 2003·Japanese Journal of Ophthalmology·Kenji InoueShiro Amano
Nov 3, 2005·Ophthalmology·Michael DiestelhorstUNKNOWN European-Canadian Latanoprost Fixed Combination Study Group
Nov 1, 2006·Ophthalmology·Michael Diestelhorst, UNKNOWN European-Canadian Latanoprost Fixed Combination Study Group

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Citations

Apr 19, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Norbert Pfeiffer, UNKNOWN TATS (Travatan Adjunctive Treatment Study) group
Jan 31, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Hiroshi Kobayashi
Feb 2, 2010·Biological & Pharmaceutical Bulletin·Ayako SugimotoYukio Ono
Jun 10, 2011·Current Medical Research and Opinion·James F T Li Yim, Donald M Montgomery
Jul 8, 2016·Advances in Therapy·Tadashi NakanoMasayuki Tatemichi
Oct 27, 2020·Journal of Glaucoma·Tony RealiniMalik Y Kahook

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