Comparison of one-day versus one-hour application of topical gatifloxacin in eliminating conjunctival bacterial flora

Ophthalmology
Jason M MossChristopher N Ta

Abstract

To compare efficacies of 1-day, 1-hour, and combined 1-day/1-hour preoperative topical gatifloxacin in eliminating conjunctival bacterial flora. Prospective, comparative case series. Sixty patients (120 eyes) scheduled to undergo anterior segment intraocular surgery at Stanford University Medical Center. Cultures were collected from the palpebral conjunctival sac at baseline and after 1 day (4 doses), 1 hour (3 doses), and 1 day/1 hour (7 doses) of gatifloxacin use. Incidence of positive bacterial samples collected pre- and post-antibiotic treatment and number of colony forming units (CFUs). SeptiChek (Becton Dickinson, Franklin Lakes, NJ) positive cultures significantly decreased from 67% growth at baseline to 28% (P<0.0001) after 1 day and from 60% at baseline to 37% (P = 0.018) after 1 hour of gatifloxacin use. Reductions of 44% growth at baseline to 12% (P = 0.0001) after 1 day and 32% at baseline to 13% (P = 0.029) after 1 hour of gatifloxacin use were observed on blood agar. Surgical eyes that received both 1-day and 1-hour preoperative gatifloxacin had reductions from 67% growth at baseline to 18% posttreatment (P<0.0001) and 45% at baseline to 7% posttreatment (P<0.0001) on SeptiChek and blood agar media, respectively. ...Continue Reading

References

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Citations

Apr 22, 2009·Advances in Therapy·Michelle C CalleganAndrea L Moyer
Sep 8, 2011·International Ophthalmology Clinics·Glenn YiuJames Chodosh
Nov 26, 2015·Ophthalmic Surgery, Lasers & Imaging Retina·Stephen J Kim, Howard F Fine
Mar 18, 2015·Acta Ophthalmologica·Line KesselJesper Hjortdal
Mar 3, 2015·International Ophthalmology Clinics·Stephen J Kim
Nov 15, 2011·Current Opinion in Ophthalmology·Charles Q Yu, Christopher N Ta
Oct 22, 2020·BioMed Research International·Zhenyu WangXuemin Li
Jul 4, 2021·Scientific Reports·Ali Riza Cenk Celebi, Ozlem Onerci Celebi

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