Abstract
To compare efficacies of 1-day, 1-hour, and combined 1-day/1-hour preoperative topical gatifloxacin in eliminating conjunctival bacterial flora. Prospective, comparative case series. Sixty patients (120 eyes) scheduled to undergo anterior segment intraocular surgery at Stanford University Medical Center. Cultures were collected from the palpebral conjunctival sac at baseline and after 1 day (4 doses), 1 hour (3 doses), and 1 day/1 hour (7 doses) of gatifloxacin use. Incidence of positive bacterial samples collected pre- and post-antibiotic treatment and number of colony forming units (CFUs). SeptiChek (Becton Dickinson, Franklin Lakes, NJ) positive cultures significantly decreased from 67% growth at baseline to 28% (P<0.0001) after 1 day and from 60% at baseline to 37% (P = 0.018) after 1 hour of gatifloxacin use. Reductions of 44% growth at baseline to 12% (P = 0.0001) after 1 day and 32% at baseline to 13% (P = 0.029) after 1 hour of gatifloxacin use were observed on blood agar. Surgical eyes that received both 1-day and 1-hour preoperative gatifloxacin had reductions from 67% growth at baseline to 18% posttreatment (P<0.0001) and 45% at baseline to 7% posttreatment (P<0.0001) on SeptiChek and blood agar media, respectively. ...Continue Reading
References
Sep 1, 1985·Archives of Ophthalmology·S J IsenbergS Khwarg
Feb 1, 1982·Archives of Surgery·G RodeheaverR Edlich
Oct 18, 1996·The Journal of Biological Chemistry·H HiasaK J Marians
Jun 27, 1998·Journal of Cataract and Refractive Surgery·S Masket
Nov 5, 2002·Ophthalmology·Christopher N TaHerminia Miño De Kaspar
May 19, 2005·Journal of Cataract and Refractive Surgery·Trevin WallinRandall J Olson
Sep 19, 2006·American Journal of Ophthalmology·Regis P KowalskiY Jerold Gordon
Citations
Mar 1, 2012·International Ophthalmology·Daphne C Y Han, Soon-Phaik Chee
Apr 22, 2009·Advances in Therapy·Michelle C CalleganAndrea L Moyer
Sep 8, 2011·International Ophthalmology Clinics·Glenn YiuJames Chodosh
Jul 10, 2010·Drugs·Robert E Fintelmann, Ayman Naseri
Jul 27, 2010·Ophthalmology·Stephen J KimTerrence J Doherty
Dec 10, 2014·Retina·Robert L AveryGeorge A Williams
Nov 26, 2015·Ophthalmic Surgery, Lasers & Imaging Retina·Stephen J Kim, Howard F Fine
Nov 17, 2015·Current Opinion in Ophthalmology·Andrzej GrzybowskiGeorge Beiko
Mar 18, 2015·Acta Ophthalmologica·Line KesselJesper Hjortdal
Mar 3, 2015·International Ophthalmology Clinics·Stephen J Kim
Dec 15, 2015·Retina·Alexa L LiRonan E OʼMalley
Nov 9, 2016·PloS One·Jinzhu HuangLaichun Lu
Nov 15, 2011·Current Opinion in Ophthalmology·Charles Q Yu, Christopher N Ta
Oct 22, 2020·BioMed Research International·Zhenyu WangXuemin Li
Jul 4, 2021·Scientific Reports·Ali Riza Cenk Celebi, Ozlem Onerci Celebi