Comparison of Oral Ibuprofen at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial

Annals of Emergency Medicine
Sergey MotovJohn Marshall

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are used extensively for the management of acute pain, with ibuprofen being one of the most frequently used oral analgesics in the emergency department (ED). We compare the analgesic efficacy of oral ibuprofen at 3 different doses for adult ED patients with acute pain. This was a randomized, double-blind trial comparing analgesic efficacy of 3 doses of oral ibuprofen (400, 600, and 800 mg) in adult ED patients with acute painful conditions. Primary outcome included difference in pain scores between the 3 groups at 60 minutes. We enrolled 225 subjects (75 per group). The difference in mean pain scores at 60 minutes between the 400- and 600-mg groups was -0.14 (95% confidence interval [CI] -0.67 to 0.39); between the 400- and 800-mg groups, 0.14 (95% CI -0.65 to 0.37); and between the 600- and 800-mg groups, 0.00 (95% CI -0.47 to 0.47). Reductions in pain scores from baseline to 60 minutes were similar for all subjects in each of the 3 groups. No adverse events occurred in any group. Oral ibuprofen administered at doses of 400, 600, and 800 mg has similar analgesic efficacy for short-term pain relief in adult patients presenting to the ED with acute pain.

Associated Clinical Trials

Feb 22, 2018·Antonios LikourezosAntonios Likourezos

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Citations

Jan 17, 2020·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Howard S KimDavid Cella
Jan 11, 2020·The Science of the Total Environment·Verónica Margarita Gutiérrez-NoyaRubi Romero
Jan 31, 2021·BMJ : British Medical Journal·Gustavo C MachadoRichard O Day
Mar 11, 2021·Expert Opinion on Pharmacotherapy·Joseph V PergolizziGiustino Varrassi
Feb 13, 2021·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Benjamin W FriedmanPolly E Bijur
Oct 27, 2020·Current Opinion in Critical Care·John A Harvin, Lillian S Kao
Mar 5, 2020·BMJ Evidence-based Medicine·Dylan Collins
Aug 19, 2021·International Journal of Environmental Health Research·Nuran Cikcikoglu YildirimSenay Basaran
Jun 17, 2021·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Eddie IrizarryBenjamin W Friedman

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