Comparison of Oral Melatonin and Midazolam as Premedication in Children Undergoing General Anesthesia for Dental Treatment

Anesthesiology and Pain Medicine
Reyhaneh FaghihianNasser Kaviani

Abstract

Dental anxiety is prevalent in children. This condition may cause uncooperative behavior and need a treatment under general anesthesia. The perioperative period, especially for children, is a stressing event. Premedication is commonly used to reduce perioperative anxiety and facilitate the induction of anesthesia. 132 children candidates for dental treatment under GA were enrolled in this study and randomly divided into 3 groups. Oral melatonin, midazolam, and normal saline were administered as premedication. Patient's sedation score before GA, the ease of intravenous line establishment, patient's need for painkillers, and duration of recovery were evaluated and compared. Regarding the sedation score and response to IV access establishment, comparisons showed statistically significant differences between melatonin and midazolam groups (P < 0.05) as well as between midazolam and placebo groups (P < 0.001). The difference between melatonin and placebo groups was not significant (P > 0.05). The need for painkiller administration was statistically different between midazolam and placebo, melatonin and placebo, and midazolam and melatonin groups (P < 0.05). A statistically significant difference was also found between melatonin and ...Continue Reading

References

Jul 1, 1987·Journal of Clinical Psychology·J D Corrigan, N S Hinkeldey
Nov 24, 1999·British Journal of Anaesthesia·M Naguib, A H Samarkandi
Jul 12, 2008·Paediatric Anaesthesia·Berrin IsikHaluk Bodur
Jul 16, 2011·International Journal of Pediatrics·Emilio J Sánchez-BarcelóRussel J Reiter
May 20, 2014·Anaesthesia·L P H AndersenI Gögenur
Mar 20, 2015·Journal of Anaesthesiology, Clinical Pharmacology·Tushar Patel, Madhuri S Kurdi
Nov 26, 2015·Journal of Biological Research·Mercedes Perez-HerediaLeticia Marchena-Rodríguez

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Methods Mentioned

BETA
sedation

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SPSS20

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