Abstract
Incidence of Bordetella pertussis, the causative agent of whooping cough, is rising in some global human populations despite high vaccination rates, and significant research is underway to address the issue. Baboons are an established model for pertussis research, but like many mammals, they can be naturally infected with Bordetella bronchiseptica. Because B. bronchiseptica interferes with B. pertussis research, it must be excluded from baboons under consideration for enrollment in pertussis studies. In addition to research-related concerns, B. bronchiseptica can sometimes cause clinical disease in baboons and other nonhuman primates. This study examined the use of antibiotics to clear B. bronchiseptica in naturally infected baboons. Thirty-five juvenile baboons were divided into five treatment groups: oral sulfamethoxazole/trimethoprim (TMS), nebulized gentamicin (gentamicin), combination (TMS + gentamicin) in positive animals, combination (TMS + gentamicin) as a prophylactic in exposed animals and no treatment (control). Combination of oral TMS and nebulized gentamicin given to positive animals was most effective, producing long-term clearance in 11 out of 12 treated animals. To avoid unnecessary use of antibiotics, our prima...Continue Reading
References
Jun 1, 1974·Chest·J KlasterskyD Daneau
Oct 1, 1983·Laboratory Animals·M BaskervilleA Baskerville
Feb 1, 1994·Thorax·D Honeybourne
Mar 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R R MacGregor, A L Graziani
Apr 16, 2005·Clinical Microbiology Reviews·Seema Mattoo, James D Cherry
Apr 22, 2005·British Journal of Clinical Pharmacology·A I Al-AmoudH Chrystyn
Oct 9, 2007·Trends in Microbiology·Shokrollah ElahiVolker Gerdts
Jan 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Steve W C ChangMichael L Platt
Jan 19, 2012·Infection and Immunity·Jason M WarfelTod J Merkel
Feb 4, 2014·Trends in Microbiology·Kingston H G MillsMieszko M Wilk
Feb 15, 2014·Diagnostic Microbiology and Infectious Disease·Anette TizolovaSophie Guillot
Sep 4, 2014·Expert Review of Vaccines·Jason M Warfel, Tod J Merkel
May 27, 2016·Clinical Microbiology Reviews·Eric WenzlerLarry H Danziger
Sep 27, 2016·The Journal of Veterinary Medical Science·Annalee W NguyenJennifer A Maynard
Feb 12, 2017·Journal of Veterinary Internal Medicine·M R LappinJ S Weese
Aug 29, 2017·Journal of the American Animal Hospital Association·Richard B FordLink V Welborn
Jul 22, 2018·Microbiology Spectrum·Kristina Kadlec, Stefan Schwarz
Apr 9, 2020·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Rachel S MeyersDavid S Hoff
Aug 14, 2020·Journal of Veterinary Internal Medicine·Aude Morgane CanonneCécile Clercx