Comparison of osteogenic potentials of visceral and subcutaneous adipose-derived cells of rabbits.

Plastic and Reconstructive Surgery
Ioana A PeptanJeremy J Mao

Abstract

The demand for a large amount of osteogenic cells required in bone tissue engineering warranted exploration of a new source of osteoprogenitor cells. Recent studies have demonstrated that adipose-derived stromal cells possess multiple differentiation capacities, including osteogenic potential, as bone marrow mesenchymal stem cells. In the present study, the authors compared the osteogenic potentials of adipose-derived stromal cells from different anatomical sites of rabbits. Different adipose-derived stromal cells were isolated from rabbit visceral and subcutaneous adipose tissues by enzymatic digestion and in vitro differentiation into osteogenic lineage. Osteogenic markers representing differentiation potentials of adipose-derived stromal cells from different anatomical sites were compared by biochemical and immunohistochemical assessment (n = 3). Fibroblast-like cells were digested from both visceral and subcutaneous adipose tissues. After exposure to osteogenic differentiation medium, visceral adipose-derived cells were found to possess greater osteogenic potentials than cells isolated from subcutaneous adipose tissues, evidenced by significantly different amounts of osteogenic markers including alkaline phosphatase, osteoc...Continue Reading

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Citations

May 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·Rafael D González-CruzEric M Darling
Aug 15, 2009·Tissue Engineering. Part a·Mirjam FröhlichGordana Vunjak-Novakovic
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