Comparison of outcomes after switching treatment from intravitreal bevacizumab to ranibizumab in neovascular age-related macular degeneration

Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Jerrod S KentTom G Sheidow

Abstract

To compare visual acuity and central retinal thickness in patients initially treated with bevacizumab (Avastin) and switched to ranibizumab (Lucentis) for neovascular age-related macular degeneration (AMD). A retrospective chart review. This study included 87 eyes from 80 patients over the age of 65 with neovascular AMD. Patients were initially treated with bevacizumab injections every 6 weeks and then switched to ranibizumab every 4 weeks when it became publicly funded by the Ontario government. Outcomes include comparison of visual acuity and central retinal thickness after bevacizumab treatment, and after switching to ranibizumab. Visual acuity improved significantly versus initial baseline values following a treatment course of 3 or more injections of bevacizumab (0.58 logMar, SD = 0.30 vs 0.73 logMar, SD = 0.41; p = 0.0007). Patients then showed a further significant improvement in visual acuity after switching and receiving a course of ranibizumab (0.51 logMar, SD = 0.32) (p = 0.0122). Mean central retinal thickness as measured by optical coherence tomography significantly decreased after a course of bevacizumab (p = 0.0158), and a further decrease was noted after a subsequent course of ranibizumab (p < 0.0001). There was...Continue Reading

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Citations

Jun 17, 2015·Expert Opinion on Biological Therapy·Mohammad Hossein YazdiMohammad Abdollahi
Jul 22, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ulrich SchraermeyerHartwig Wolburg
Oct 12, 2016·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Jae Hyung LeeSung Eun Kim
Nov 15, 2016·Ophthalmic Surgery, Lasers & Imaging Retina·Chelsea FechterDennis M Marcus
Jun 20, 2018·European Journal of Ophthalmology·Rita EhrlichItay Chowers
Jul 2, 2014·European Journal of Ophthalmology·Cem KüçükerdönmezMartin Alexander Leitritz
Oct 12, 2017·Ophthalmic Surgery, Lasers & Imaging Retina·Karen Jhi Wen ChiaAugustinus Laude

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