Abstract
Acute exacerbations in patients with chronic rhinosinusitis (CRS) are often treated with courses of systemic antibiotics. Poor correlation between microbiologic culture results and the sinus microbiome in CRS has caused increased debate as to the relevance of culture-directed antibiotics. There is currently sparse data comparing outcomes of culture-directed antibiotics vs non-culture-directed antibiotics for treatment of CRS. This work reports a retrospective review. A total of 946 CRS patients treated with antibiotics were examined; 122 CRS patients with acute exacerbations were treated with culture-directed (n = 61) vs empiric (n = 61) antibiotics. Lund-Kennedy (LK) and 22-item Sino-Nasal Outcome Test (SNOT-22) scores were compared pretreatment and posttreatment, with short-term (<1 month) and long-term (1-6 months) follow-up. Patient demographics, comorbidities, and prior surgical history were collected. Both groups had similar pretreatment SNOT-22 scores (p = 0.25) while the culture group had higher baseline LK endoscopy scores (p < 0.01). All data were adjusted for pertinent comorbidities, surgical history, co-therapeutics, and baseline scores. There was no difference in improvement in culture-directed and empirically trea...Continue Reading
References
Dec 5, 2002·Journal of Chemotherapy·G NamyslowskiH Misiolek
May 17, 2006·Anaerobe·Itzhak Brook
Sep 7, 2006·The Laryngoscope·Hakan Cincik, Berrylin J Ferguson
Oct 2, 2009·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·C HopkinsJ P Browne
Feb 19, 2011·American Journal of Epidemiology·Hude QuanVijaya Sundararajan
Dec 7, 2011·International Forum of Allergy & Rhinology·Leah M FeazelVijay R Ramakrishnan
Apr 4, 2012·Rhinology·Wytske J FokkensPeter John Wormald
May 10, 2013·BMC Infectious Diseases·Sam BoasePeter-John Wormald
Jul 12, 2013·International Forum of Allergy & Rhinology·Cindy M LiuAndrew P Lane
Aug 31, 2013·The Journal of Allergy and Clinical Immunology·Stephanie Shintani SmithRobert C Kern
Jan 15, 2014·International Forum of Allergy & Rhinology·Zi ZhangEbbing Lautenbach
Oct 4, 2014·International Forum of Allergy & Rhinology·Leah J HauserVijay R Ramakrishnan
Apr 4, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Richard M RosenfeldMaureen D Corrigan
Jun 21, 2015·American Journal of Otolaryngology·Zi Yang JiangPete S Batra
Aug 1, 2015·International Forum of Allergy & Rhinology·Mark A MerkleySteven R Gill
Feb 18, 2016·International Forum of Allergy & Rhinology·Richard R OrlandiPeter H Hwang
Feb 20, 2016·International Forum of Allergy & Rhinology·Richard R OrlandiDavid W Kennedy
Apr 18, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·I Brook
May 5, 2016·Nature·Hilary P BrowneTrevor D Lawley
Sep 10, 2016·International Forum of Allergy & Rhinology·Henrique Augusto Cantareira SabinoEdwin Tamashiro
Dec 3, 2016·Clinical Microbiology Reviews·Michael HoggardRichard G Douglas
Jan 10, 2018·International Forum of Allergy & Rhinology·Craig Miller, Greg E Davis
Citations
Aug 22, 2018·International Forum of Allergy & Rhinology·David W Kennedy
Jul 31, 2019·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Katie M PhillipsAhmad R Sedaghat
Oct 9, 2019·Antibiotics·Joanna SzaleniecMaciej Szaleniec
Jun 8, 2019·International Forum of Allergy & Rhinology·Timothy L Smith
Nov 26, 2020·International Forum of Allergy & Rhinology·Richard R OrlandiBing Zhou
Oct 7, 2021·The Journal of Laryngology and Otology·A WozniakJ Szaleniec