PMID: 9436283Jan 1, 1997Paper

Comparison of pathologic characteristics of T1c and non-T1c cancers detected in a population-based screening study, the European Randomized Study of Screening for Prostate Cancer

World Journal of Urology
R F HoedemaekerF H Schröder

Abstract

In recent years the introduction of serum prostate-specific antigen (PSA) determination as a screening tool for early detection of prostate cancer in asymptomatic men has led to a markedly increased detection of prostate cancers that are neither palpable nor visible with transrectal ultrasonography (stage T1c). In this preliminary study we assessed pathologic features and aspects that are indicative of clinical significance in T1c tumors and tumors with palpable or visible lesions (non-T1c tumors). Between June 1994 and December 1995, 51 consecutive radical prostatectomies were performed on screened participants in the Rotterdam section of the European Randomized Study of Screening for Prostate Cancer (ERSPC). After determination of pathologic stage and Gleason score, morphometric analysis was performed to determine tumor volume. Radical prostatectomy specimens were divided into three mutually exclusive subsets: T1c tumors, non-T1c tumors with preoperative PSA levels below 4 ng/ml, and non-T1c tumors with PSA levels equal to or greater than 4 ng/ml. These subsets were compared for differences in the distribution of tumor volume, pathologic stage, and Gleason score. An arbitrarily constructed categorization model was used to ass...Continue Reading

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Citations

Apr 6, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R Postma, F H Schröder
Dec 1, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·Peter S Bunting
Sep 8, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Theo H van der KwastUNKNOWN ISUP Prostate Cancer Group
Mar 2, 2002·BJU International·A N VisF H Schröder
Dec 12, 2001·BJU International·F H SchröderUNKNOWN Rotterdam Study Group of the 'European Randomised Study of Screening for Prostate Cancer' (ERSPC)
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Aug 2, 2001·Journal of the National Cancer Institute·R F HoedemaekerF H Schröder
Feb 27, 2004·BJU International·F H SchröderUNKNOWN ERSPC
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Aug 29, 2006·European Urology·André N VisTheo H van der Kwast
Feb 25, 2000·The Journal of Urology·F H SchröderR Kranse
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May 29, 2013·Nature Reviews. Urology·Theo H Van der Kwast, Monique J Roobol
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