Comparison of pathways associated with hepatitis B- and C-infected hepatocellular carcinoma using pathway-based class discrimination method

Genomics
Sun Young LeeBu-Yeo Kim

Abstract

Molecular signatures causing hepatocellular carcinoma (HCC) from chronic infection of hepatitis B virus (HBV) or hepatitis C virus (HCV) are not clearly known. Using microarray datasets composed of HCV-positive HCC or HBV-positive HCC, pathways that could discriminate tumor tissue from adjacent non-tumor liver tissue were selected by implementing nearest shrunken centroid algorithm. Cancer-related signaling pathways and lipid metabolism-related pathways were predominantly enriched in HCV-positive HCC, whereas functionally diverse pathways including immune-related pathways, cell cycle pathways, and RNA metabolism pathways were mainly enriched in HBV-positive HCC. In addition to differentially involved pathways, signaling pathways such as TGF-β, MAPK, and p53 pathways were commonly significant in both HCCs, suggesting the presence of common hepatocarcinogenesis process. The pathway clustering also verified segregation of pathways into the functional subgroups in both HCCs. This study indicates the functional distinction and similarity on the pathways implicated in the development of HCV- and/or HBV-positive HCC.

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Citations

Apr 20, 2018·Journal of Gastroenterology and Hepatology·Veerabrahma Pratap SeshachalamKam M Hui
Apr 18, 2020·Cancer Causes & Control : CCC·Preetha RajkumarRajkumar Lakshmanaswamy
Jun 3, 2021·International Journal of Molecular Sciences·Elisabeth M HaberlChrista Buechler
Nov 24, 2021·Immunity, Inflammation and Disease·Xinye QianJun Yan

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