Comparison of patient-controlled analgesia with and without nighttime morphine infusion following lower extremity surgery in children

Journal of Pain and Symptom Management
J K McNeely, N C Trentadue

Abstract

To evaluate the usefulness of a concurrent nighttime morphine infusion in pediatric patient-controlled analgesia (PCA), 36 school-age children undergoing elective lower extremity surgery were randomly assigned to receive morphine by PCA alone, or PCA with a nighttime infusion of morphine (PCA+BI). Postoperatively, patients breathed air and had oxygen saturation recorded continuously for the duration of PCA use. Total morphine requirements were decreased in the PCA group as compared to PCA+BI patients. PCA pump activation, VAS pain, and sedation scores were similar between the two groups at all times. Compared to the PCA group, patients assigned to the PCA+BI group spent more time with SpO2 of 90% or less, during the nighttime infusion (P < 0.05). The use of a nighttime infusion of morphine did not appear to offer any advantage over the use of PCA alone in this patient population.

Associated Clinical Trials

References

Jul 1, 1990·Anaesthesia·J G JonesR G Wheatley
Jan 1, 1995·Anesthesia and Analgesia·C D Kurth
Jan 1, 1995·Anesthesia and Analgesia·D C TylerA Lloyd-Thomas
Mar 1, 1993·Anesthesia and Analgesia·R J Geller

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Citations

Sep 21, 2001·Indian Journal of Pediatrics·M Yaster, D G Nichols
Sep 29, 1999·Pharmacology & Therapeutics·A R Lloyd-Thomas
Dec 1, 2006·Pain Practice : the Official Journal of World Institute of Pain·D WamboldA D Rosenberg
Oct 4, 2002·The New England Journal of Medicine·Charles B Berde, Navil F Sethna
Oct 4, 2006·Current Opinion in Anaesthesiology·A D Rosenberg
Oct 22, 2008·The Clinical Journal of Pain·Michelle L CzarneckiSteven J Weisman
Jul 19, 2008·Anesthesia and Analgesia·Elliot J Krane
Jun 29, 2007·Paediatric Anaesthesia·Tina Hoff Duedahl, Ebba Holme Hansen
Jul 13, 2005·Pediatric Clinics of North America·Christine Greco, Charles Berde
Mar 15, 2002·Anesthesiology Clinics of North America·Sabine Kost-Byerly
Jul 20, 2001·British Journal of Anaesthesia·P E Macintyre
Jan 15, 2014·European Journal of Cancer Care·J CuiJ J Zhao
Aug 29, 2019·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Diana V Liu, Yuan-Chi Lin
Nov 4, 2017·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Michelle L CzarneckiSteven J Weisman
May 17, 2001·Paediatric Drugs·A J McDonald, M G Cooper
Oct 24, 2020·Paediatric Drugs·Christopher S LeeVidya Chidambaran

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