Comparison of patient (POEM), observer (EASI, SASSAD, TIS) and corneometry measures of emollient effectiveness in children with eczema: findings from the COMET feasibility trial

The British Journal of Dermatology
Matthew J RiddChris Metcalfe

Abstract

Eczema affects around 20% of children, but multiple different outcome measures have hampered research into the effectiveness of different treatments. To compare the change in scores and correlations within and between five measures of eczema severity: Patient-Orientated Eczema Measure (POEM), Eczema Area and Severity Index (EASI), Six Area, Six Sign Atopic Dermatitis (SASSAD), Three Item Severity (TIS) and skin hydration (corneometry). Data from a feasibility trial that randomized young children with eczema to one of four emollients were used. Participants were followed for 3 months (84 days). Descriptive statistics (by emollient over time) and Spearman's correlation coefficients comparing scores at each time point and absolute change (between adjacent time points) for each outcome measure were calculated. In total, 197 children, mean ± SD age 21·7 ± 12·8 months, were randomized. POEM and TIS appeared to capture a range of eczema severity at baseline, but only POEM had close approximation to normal distribution. Mean POEM, EASI, SASSAD and TIS scores improved month by month, with POEM showing the greatest sensitivity (effect size 0·42). Correlations within POEM, EASI, SASSAD and TIS were moderate to good, decreasing over time. ...Continue Reading

References

Oct 21, 2006·Journal of the American Academy of Dermatology·Elisabeth A HolmGregor B E Jemec
Aug 4, 2007·The British Journal of Dermatology·E A HolmG B E Jemec
Apr 18, 2012·Clinics in Dermatology·Bahman Sotoodian, Howard I Maibach
Aug 8, 2012·Trials·Paula R WilliamsonPeter Tugwell
Sep 17, 2013·The Journal of Allergy and Clinical Immunology·Jochen SchmittUNKNOWN Harmonising Outcome Measures for Atopic Dermatitis (HOME) Initiative
Apr 22, 2015·The British Journal of Dermatology·C Y ZhaoD F Murrell
Jun 21, 2016·Allergy·L A A GerbensUNKNOWN Harmonising Outcome Measures for Eczema (HOME) initiative
Aug 23, 2016·The British Journal of Dermatology·H NankervisH C Williams

❮ Previous
Next ❯

Citations

Oct 28, 2019·BMJ : British Medical Journal·Matthew J RiddHywel C Williams

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.