Comparison of patient-specific computational models vs. clinical follow-up, for adjacent segment disc degeneration and bone remodelling after spinal fusion

PloS One
Marc van RijsbergenK Ito

Abstract

Spinal fusion is a standard surgical treatment for patients suffering from low back pain attributed to disc degeneration. However, results are somewhat variable and unpredictable. With fusion the kinematic behaviour of the spine is altered. Fusion and/or stabilizing implants carrying considerable load and prevent rotation of the fused segments. Associated with these changes, a risk for accelerated disc degeneration at the adjacent levels to fusion has been demonstrated. However, there is yet no method to predict the effect of fusion surgery on the adjacent tissue levels, i.e. bone and disc. The aim of this study was to develop a coupled and patient-specific mechanoregulated model to predict disc generation and changes in bone density after spinal fusion and to validate the results relative to patient follow-up data. To do so, a multiscale disc mechanoregulation adaptation framework was developed and coupled with a previously developed bone remodelling algorithm. This made it possible to determine extra cellular matrix changes in the intervertebral disc and bone density changes simultaneously based on changes in loading due to fusion surgery. It was shown that for 10 cases the predicted change in bone density and degeneration gr...Continue Reading

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Citations

Aug 20, 2020·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Eylül Demirİhsan Toktaş
Dec 1, 2020·Global Spine Journal·G Michael MallowDino Samartzis
Feb 16, 2021·Frontiers in Bioengineering and Biotechnology·Sebastiano CapraraMarco Senteler
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Jan 16, 2021·International Journal of Molecular Sciences·Laura BaumgartnerJérôme Noailly
Mar 7, 2021·Bioengineering·André P G Castro
Apr 27, 2021·Journal of Orthopaedic Translation·Peter Endre EltesAron Lazary
Jun 8, 2021·Frontiers in Bioengineering and Biotechnology·Clément D FavierAndrew T M Phillips
Jun 25, 2021·Frontiers in Bioengineering and Biotechnology·Minhao ZhouGrace D O'Connell

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