Comparison of perineural platelet-rich plasma and dextrose injections for moderate carpal tunnel syndrome: A prospective randomized, single-blind, head-to-head comparative trial

Journal of Tissue Engineering and Regenerative Medicine
Yu-Ping ShenYung-Tsan Wu

Abstract

Recent studies demonstrated the utility of perineural injection with platelet-rich plasma (PRP) and 5% dextrose (D5W) as novel strategies for treatment of carpal tunnel syndrome (CTS). The present study comprised a prospective, randomized, single-blind, head-to head comparative trial to compare the 6-month outcome of perineural injection with PRP or D5W in patients with moderate CTS. Fifty-two patients with unilateral moderate CTS were enrolled and randomized into two groups: The PRP group received a single 3-cc perineural injection of PRP under ultrasound guidance, and dextrose group received a single 3-cc perineural injection of D5W under ultrasound guidance. The Boston Carpal Tunnel Syndrome Questionnaire score was used as the primary outcome. Secondary outcomes included cross-sectional area (CSA) of the median nerve and electrophysiological assessments. Evaluations were performed at baseline and at 1, 3, and 6 months postinjection. All patients (26 patients per group) completed the study. Compared with the dextrose group, the PRP group demonstrated significant reductions in Boston Carpal Tunnel Syndrome Questionnaire function at 3 months (p = .044), distal motor latency at 6 months (p = .028), and CSA at 3 and 6 months (p =...Continue Reading

Associated Clinical Trials

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Citations

Sep 30, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Seniz AkcayMahmut Eren
Apr 23, 2021·British Medical Bulletin·Lorenzo GiordanoNicola Maffulli
May 8, 2021·The Journal of Hand Surgery·Kristin E KarimMichael S Murphy
Jun 10, 2021·International Journal of Clinical Practice·Yu-Ping ShenYung-Tsan Wu

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